Issue 13, 2024

A waste-minimized approach for the synthesis of iodinated organic borazines

Abstract

We herein report a waste-minimized process for the synthesis of iodinated hexa-aryl borazines in different iodination patterns and amounts. Access to these widely promising B–N-containing materials features several synthetic challenges including low solubility, narrow stability/reactivity, and limited selectivity. Therefore, the development of synthetic procedures also faces evident sustainability challenges. We have tackled these aspects by merging unconventional activation techniques with metrics-oriented synthetic design. Herein, we report a protocol that enables a fast access route to iodinated borazines which are useful substrates to access different post-functionalized more complex materials. The protocol uses simple and benign chemicals, is waste minimized (E-factor 2.79), and produces iodinated hexa-aryl borazines in good to excellent yields. An evaluation of green metrics, including EcoScale, is provided to quantify the advantages associated with the newly defined protocol.

Graphical abstract: A waste-minimized approach for the synthesis of iodinated organic borazines

Supplementary files

Article information

Article type
Paper
Submitted
06 Feb 2024
Accepted
08 Apr 2024
First published
09 Apr 2024
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2024,26, 7752-7758

A waste-minimized approach for the synthesis of iodinated organic borazines

D. Marchionni, D. Gernini, A. Nazari Khodadadi, E. Cela, F. Huang and L. Vaccaro, Green Chem., 2024, 26, 7752 DOI: 10.1039/D4GC00699B

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