Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions†
Carolyn J.
Karns, 
a
Taylor P.
Spidle,
‡ab
Emmanuel
Adusah,
‡b
Mingze
Gao,
a
Jennifer E.
Nehls
a
and
Michael W.
Beck
*b
a
Taylor P.
Spidle,
‡ab
Emmanuel
Adusah,
‡b
Mingze
Gao,
a
Jennifer E.
Nehls
a
and
Michael W.
Beck
*b
Abstract
Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. Here, fluorogenic tools for measuring CES1 activity are developed and demonstrated to report on these factors in living cells. These tools enable experiments that will develop a deeper understanding of CES1 metabolism.
- This article is part of the themed collection: 2024 Emerging Investigators
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