Issue 16, 2024

Application of biomaterials in the treatment of intracerebral hemorrhage

Abstract

Although the current surgical hematoma removal treatment saves patients’ lives in critical moments of intracerebral hemorrhage (ICH), the lethality and disability rates of ICH are still very high. Due to the individual differences of patients, postoperative functional improvement is still to be confirmed, and the existing drug treatment has limited benefits for ICH. Recent advances in biomaterials may provide new ideas for the therapy of ICH. This review first briefly describes the pathogenic mechanisms of ICH, including primary and secondary injuries such as inflammation and intracerebral edema, and briefly describes the existing therapeutic approaches and their limitations. Secondly, existing nanomaterials and hydrogels for ICH, including exosomes, liposomes, and polymer nanomaterials, are also described. In addition, the potential challenges and application prospects of these biomaterials for clinical translation in ICH treatment are discussed.

Graphical abstract: Application of biomaterials in the treatment of intracerebral hemorrhage

Article information

Article type
Review Article
Submitted
06 Mai 2024
Accepted
28 Jun 2024
First published
03 Jul 2024

Biomater. Sci., 2024,12, 4065-4082

Application of biomaterials in the treatment of intracerebral hemorrhage

W. Wang, X. Liu, Y. Wang, D. Zhou and L. Chen, Biomater. Sci., 2024, 12, 4065 DOI: 10.1039/D4BM00630E

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