Issue 13, 2023

Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

Abstract

Bacteria resistant to antibiotics present a threat to public health. The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid, and several of their epimers, have been identified from the pathogenic Gram-negative bacteria, which have been proposed to associate with bacterial infection/pathogenicity, immune escape, and so on. The intriguing structures and less-understood biological functions make them attractive synthetic targets for biological studies and drug discovery. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures that were reported in the past two decades are summarised, together with recent progress on the application of synthetic non-2-ulosonic acid derivatives.

Graphical abstract: Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

Supplementary files

Article information

Article type
Review Article
Submitted
28 Apr 2023
Accepted
29 Mai 2023
First published
02 Jun 2023

Org. Chem. Front., 2023,10, 3429-3446

Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

X. Guo, P. Li, H. Liu and X. Li, Org. Chem. Front., 2023, 10, 3429 DOI: 10.1039/D3QO00637A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements