Issue 19, 2023

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Abstract

Biocatalytic asymmetric reduction of alkenes in organic solvent is attractive for enantiopurity and product isolation, yet remains under developed. Herein we demonstrate the robustness of an ene reductase immobilised on Celite for the reduction of activated alkenes in micro-aqueous organic solvent. Full conversion was obtained in methyl t-butyl ether, avoiding hydrolysis and racemisation of products. The immobilised ene reductase showed reusability and a scale-up demonstrated its applicability.

Graphical abstract: Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Supplementary files

Article information

Article type
Communication
Submitted
19 Apr 2023
Accepted
22 Mai 2023
First published
22 Mai 2023
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2023,13, 5530-5535

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

R. Villa, C. Ferrer-Carbonell and C. E. Paul, Catal. Sci. Technol., 2023, 13, 5530 DOI: 10.1039/D3CY00541K

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