Issue 15, 2021

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduction to CO in living cells for hypoxia tumor treatment

Abstract

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid the low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However, intracellular in situ generation of CO for hypoxia tumor treatment remains challenging. Herein, photoactive conjugated polymer/graphdiyne nanocatalyst (CP@GDY/DSPE-PEG) was constructed to in situ reduce endogenous carbon dioxide (CO2) into CO for hypoxia tumor therapy. Under light irradiation, the CO production rates of PFP@GDY/DSPE-PEG and PBF@GDY/DSPE-PEG reached 23 μmol h−1 gmat−1 and 31 μmol h−1 gmat−1 respectively, which can significantly affect mitochondrial respiration, leading to cancer cell apoptosis. Thus, the therapeutic effect of catalysis from metabolic CO2 into CO therapy under hypoxia conditions was achieved. This work provides a conjugated polymer/graphdiyne nanocatalyst to in situ generate CO for hypoxia tumor treatment.

Graphical abstract: Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduction to CO in living cells for hypoxia tumor treatment

Supplementary files

Article information

Article type
Research Article
Submitted
09 Mai 2021
Accepted
13 Jun 2021
First published
14 Jun 2021

Mater. Chem. Front., 2021,5, 5841-5845

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduction to CO in living cells for hypoxia tumor treatment

E. Zhang, Z. Zuo, W. Yu, H. Zhao, S. Xia, Y. Huang, F. Lv, L. Liu, Y. Li and S. Wang, Mater. Chem. Front., 2021, 5, 5841 DOI: 10.1039/D1QM00677K

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