Issue 87, 2021

Immobilisation and flow chemistry: tools for implementing biocatalysis

Abstract

The merger of enzyme immobilisation and flow chemistry has attracted the attention of the scientific community during recent years. Immobilisation enhances enzyme stability and enables recycling, flow chemistry allows process intensification. Their combination is desirable for the development of more efficient and environmentally friendly biocatalytic processes. In this feature article, we aim to point out important metrics for successful enzyme immobilisation and for reporting flow biocatalytic processes. Relevant examples of immobilised enzymes used in flow systems in organic, biphasic and aqueous systems are discussed. Finally, we describe recent developments to address the cofactor recycling hurdle.

Graphical abstract: Immobilisation and flow chemistry: tools for implementing biocatalysis

Article information

Article type
Feature Article
Submitted
06 Aug 2021
Accepted
05 Okt 2021
First published
05 Okt 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 11416-11428

Immobilisation and flow chemistry: tools for implementing biocatalysis

J. Coloma, Y. Guiavarc’h, P. Hagedoorn and U. Hanefeld, Chem. Commun., 2021, 57, 11416 DOI: 10.1039/D1CC04315C

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