Issue 59, 2020

Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

Abstract

Herein, we have developed a novel and simple protocol to realize the C–H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(I) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

Graphical abstract: Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2020
Accepted
19 Mai 2020
First published
19 Mai 2020

Chem. Commun., 2020,56, 8202-8205

Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

Y. Li, Z. Tang, J. Zhang and L. Liu, Chem. Commun., 2020, 56, 8202 DOI: 10.1039/D0CC01118E

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