Issue 25, 2019

Chiral palladium pincer complexes for asymmetric catalytic reactions

Abstract

Palladium pincer complexes, containing a monoanionic terdentate ligand composed of an anionic aryl carbon atom and two mutually compatible donor sites, have aroused considerable interest since their first reports in the late 1970s. The high stability of the Pd pincer complexes and particularly their high modularity make these species ideal candidates for catalysis. Furthermore, the nature of the meridional coordination of the pincer ligands, and along with this their ability to enforce a stereo-specific environment around the Pd center, provide a good opportunity for developing chiral Pd pincer catalysts. Thus, a broad variety of chiral Pd pincer complexes have been prepared by the introduction of various stereochemical centers in the pincer skeletons. These chiral Pd pincer complexes have been successfully applied to many asymmetric catalytic reactions such as hydrophosphination reactions, allylation of aldehydes and imines, Michael and aldol reactions, Suzuki–Miyaura reactions as well as reactions of nitrile compounds with imines. This review focuses on the synthetic methods and the applications of chiral Pd pincer complexes in asymmetric catalysis.

Graphical abstract: Chiral palladium pincer complexes for asymmetric catalytic reactions

Article information

Article type
Review Article
Submitted
18 Feb 2019
Accepted
07 Mai 2019
First published
07 Mai 2019

Org. Biomol. Chem., 2019,17, 6069-6098

Chiral palladium pincer complexes for asymmetric catalytic reactions

J. Liu, J. Gong and M. Song, Org. Biomol. Chem., 2019, 17, 6069 DOI: 10.1039/C9OB00401G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements