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Issue 31, 2019
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Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

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Abstract

The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.

Graphical abstract: Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

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Article information


Submitted
28 Okt 2018
Accepted
11 Mrz 2019
First published
19 Mrz 2019

Chem. Commun., 2019,55, 4519-4522
Article type
Communication

Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

C. Huo, D. Dhara, S. M. Baliban, S. Tahmasebi Nick, Z. Tan, R. Simon, A. K. Misra and X. Huang, Chem. Commun., 2019, 55, 4519
DOI: 10.1039/C8CC08622B

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