Issue 35, 2018

Combining transition metals and transient directing groups for C–H functionalizations

Abstract

In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C–H bonds, transition metal catalyzed directing group (DG) aided C–H bond activation is the most explored pathway of all because of its ability to perform diverse site selective functional metamorphosis. Despite its popularity, tedious synthetic methodology requiring additional steps for the installation and removal of DGs from the target substrate diminishes its efficacy. However, replacement of directing groups by transient directing groups (tDGs) reduces the hurdle to a greater extent without compromising the product yield and selectivity. In this report we have depicted the intense journey of transient directing groups with three (Rh, Ru, and Pd) prevalent second row transition metals.

Graphical abstract: Combining transition metals and transient directing groups for C–H functionalizations

Article information

Article type
Review Article
Submitted
15 Apr 2018
Accepted
14 Mai 2018
First published
29 Mai 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 19456-19464

Combining transition metals and transient directing groups for C–H functionalizations

T. Bhattacharya, S. Pimparkar and D. Maiti, RSC Adv., 2018, 8, 19456 DOI: 10.1039/C8RA03230K

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