Issue 4, 2018

Catalytic asymmetric enamine protonation reaction

Abstract

Enantioselective protonation, delivery of a proton to a carbanion intermediate, is the most straightforward and fundamental method for the preparation of a chiral tertiary carbon stereocenter. Recent efforts for this objective have been realized through enamine catalysis, which has now become a prominent catalytic strategy enabling a range of fascinating chiral transformations. This review will summarize recent advances in the field of enantioselective enamine protonation for the synthesis of optically active carbonyl compounds. Dynamic kinetic resolutions of α-substituted carbonyl compounds through enamine intermediates will be discussed as well.

Graphical abstract: Catalytic asymmetric enamine protonation reaction

Article information

Article type
Review Article
Submitted
24 Okt 2017
Accepted
16 Dez 2017
First published
18 Dez 2017

Org. Biomol. Chem., 2018,16, 510-520

Catalytic asymmetric enamine protonation reaction

N. Fu, L. Zhang and S. Luo, Org. Biomol. Chem., 2018, 16, 510 DOI: 10.1039/C7OB02615C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements