Issue 4, 2017

A mild catalytic system for radical conjugate addition of nitrogen heterocycles

Abstract

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.

Graphical abstract: A mild catalytic system for radical conjugate addition of nitrogen heterocycles

Supplementary files

Article information

Article type
Edge Article
Submitted
17 Jan 2017
Accepted
13 Feb 2017
First published
13 Feb 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 3121-3125

A mild catalytic system for radical conjugate addition of nitrogen heterocycles

R. A. Aycock, H. Wang and N. T. Jui, Chem. Sci., 2017, 8, 3121 DOI: 10.1039/C7SC00243B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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