Issue 14, 2024

Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview

Abstract

The strategic installation of the “magic methyl” group at a certain location in lead compounds has become an important tool for medicinal chemists in the field of drug discovery. Both photochemistry and electrochemistry have witnessed an explosive resurgence in recent years and emerged as a cornerstone of modern organic chemistry. In this review, we conducted an extensive data mining of the literature and provide a comprehensive overview of the recent advancements in utilizing green photochemical and electrochemical methodologies for the incorporation of methyl groups, with specific emphasis on the methyl source, design strategies and reaction mechanisms. These research developments provide sustainable and broadly applicable tools to develop valuable methylated products with major prospects for the pharmaceutical industry. In addition, their applications in the late-stage functionalization of bioactive compounds are also demonstrated.

Graphical abstract: Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview

Article information

Article type
Tutorial Review
Submitted
19 Feb 2024
Accepted
23 Mai 2024
First published
24 Mai 2024

Green Chem., 2024,26, 8161-8203

Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview

F. Liao, Z. Wei, Y. Guan, Z. Zhuang, K. Xu and J. Tan, Green Chem., 2024, 26, 8161 DOI: 10.1039/D4GC00848K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements