Issue 14, 2023

Glutathione depletion-mediated in situ transformation of Prussian blue nanocubes for enhanced tumor-specific imaging and photoimmunotherapy

Abstract

Tumor imaging and photoimmunotherapy hold great promise for precise and efficient tumor treatment. However, a tumor microenvironment (TME) with high redox level inhibits reactive oxygen species-mediated treatment and immune response. The traditional “always-on” phototheranostic agents have often restricted the clinical translation due to their non-specific imaging signal and phototoxicity. Herein, a novel glutathione (GSH) depletion-mediated in situ transformation strategy is proposed, and the precursors of Berlin green nanocubes can be transformed into Prussian blue nanocubes (denoted as t-PB NCs) both in tumor cells and dendritic cells (DCs), which significantly enhance the accuracy of tumor-specific three-dimensional photoacoustic imaging and tumor regional phototherapy, reducing cytotoxic effects towards healthy cells. Moreover, with GSH depletion, t-PB NCs can also enhance phototherapy to induce powerful immunogenic cell death (ICD) and promote DC maturation. Thus, this many-birds-with-one-stone GSH depletion-mediated in situ transformation strategy paves the way for tumor-specific precise photoacoustic imaging and efficient photoimmunotherapy.

Graphical abstract: Glutathione depletion-mediated in situ transformation of Prussian blue nanocubes for enhanced tumor-specific imaging and photoimmunotherapy

Supplementary files

Article information

Article type
Research Article
Submitted
08 Mrz 2023
Accepted
30 Mrz 2023
First published
01 Apr 2023

Inorg. Chem. Front., 2023,10, 4054-4064

Glutathione depletion-mediated in situ transformation of Prussian blue nanocubes for enhanced tumor-specific imaging and photoimmunotherapy

S. Tang, B. Zhou, W. Sun, C. Zhu, Y. Tang, B. Jiang and X. Shen, Inorg. Chem. Front., 2023, 10, 4054 DOI: 10.1039/D3QI00441D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements