Issue 48, 2008
From the journal:

Chemical Communications

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery†

Ahn Na Koo,a   Hong Jae Lee,a   Sung Eun Kim,a   Jeong Ho Chang,a   Chiyoung Park,b   Chulhee Kim,b   Jae Hyung Parkc  and  Sang Cheon Lee*a  

* Corresponding authors

a Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul, Korea
E-mail: sclee@kicet.re.kr
Fax: +82 2 3282 7811
Tel: +82 2 3282 2469

b Department of Polymer Science andEngineering, Hyperstructured Organic Materials Research Center, Inha University, Incheon, Korea

c Departments of Advanced Polymer and Nanopharmaceutical Sciences, Kyung Hee University, Gyeonggi-do, Korea

Abstract

We report biocompatible, cell-permeable core–shell–corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Graphical abstract: Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/B815918A
Article type
Communication
Submitted
11 Sep 2008
Accepted
28 Oct 2008
First published
12 Nov 2008

Chem. Commun., 2008, 6570-6572

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Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

A. N. Koo, H. J. Lee, S. E. Kim, J. H. Chang, C. Park, C. Kim, J. H. Park and S. C. Lee, Chem. Commun., 2008, 6570 DOI: 10.1039/B815918A

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