Issue 38, 2024

Exploring mitochondrial targeting: an innovative fluorescent probe reveals Nernstian potential and partitioning combination

Abstract

This study introduces a paradigm-shifting approach to optimize mitochondrial targeting. Employing a new fluorescent probe strategy, we unravel a combined influence of both Nernst potential (Ψ) and partitioning (P) contributions. Through the synthesis of new benz[e]indolinium-derived probes, our findings redefine the landscape of mitochondrial localization by optimizing the efficacy of mitochondrial probe retention in primary cortical neurons undergoing normoxia and oxygen–glucose deprivation. This methodology not only advances our understanding of subcellular dynamics, but also holds promise for transformative applications in biomedical research and therapeutic development.

Graphical abstract: Exploring mitochondrial targeting: an innovative fluorescent probe reveals Nernstian potential and partitioning combination

Supplementary files

Article information

Article type
Communication
Submitted
12 Mär 2024
Accepted
15 Apr 2024
First published
15 Apr 2024

Chem. Commun., 2024,60, 5062-5065

Exploring mitochondrial targeting: an innovative fluorescent probe reveals Nernstian potential and partitioning combination

J. Ordóñez-Hernández, D. Ceballos-Ávila, F. H. Real, L. B. Tovar-Y-Romo and A. Jiménez-Sánchez, Chem. Commun., 2024, 60, 5062 DOI: 10.1039/D4CC01144A

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