Issue 13, 2018

Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

Abstract

Herein, we report the first Pd-catalyzed carbonylation of unactivated aryl C–H bonds in benzamides under 1 atm of CO2 to directly afford important phthalimides. A variety of phthalimides are synthesized in moderate to high yields under redox-neutral conditions. This transformation features high regio- and chemo-selectivity, step-economy, good functional group tolerance, broad substrate scope and smooth scalability. Mechanistic studies suggest that the palladacycle is a competent intermediate.

Graphical abstract: Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

Supplementary files

Article information

Article type
Research Article
Submitted
28 Apr 2018
Accepted
15 Mai 2018
First published
29 Mai 2018

Org. Chem. Front., 2018,5, 2086-2090

Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

L. Song, G. Cao, W. Zhou, J. Ye, Z. Zhang, X. Tian, J. Li and D. Yu, Org. Chem. Front., 2018, 5, 2086 DOI: 10.1039/C8QO00433A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements