Issue 48, 2018

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Abstract

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

Graphical abstract: Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Supplementary files

Article information

Article type
Communication
Submitted
28 Okt 2018
Accepted
22 Nov 2018
First published
27 Nov 2018

Org. Biomol. Chem., 2018,16, 9373-9376

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Z. Pei, M. Yang, L. Li, X. Jian, Y. Yin, D. Li, H. Pan, Y. Lu, W. Jiang and G. Tang, Org. Biomol. Chem., 2018, 16, 9373 DOI: 10.1039/C8OB02665C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements