Issue 11, 2002

The use of FTICR-MS to detect chemical tags from a combinatorial library

Abstract

The use of tagging in combinatorial chemistry permits tracking of the solid phase as it is taken through iterative split and mix cycles. Several analytical approaches to the identification of tags (and hence the chemical history of the support) have been described. We describe herein a novel chemical tagging strategy for combinatorial solid phase chemistry. The identities of the tags attached to a single bead are discovered by the high resolution, accurate mass technique of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS).

Article information

Article type
Tutorial Review
Submitted
23 Apr 2002
Accepted
01 Okt 2002
First published
18 Okt 2002

Analyst, 2002,127, 1399-1406

The use of FTICR-MS to detect chemical tags from a combinatorial library

M. H. Todd and C. Abell, Analyst, 2002, 127, 1399 DOI: 10.1039/B203957P

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