Issue 7, 2024

High-efficiency non-thermal plasma synthesis of imine macrocycles

Abstract

Macrocycles are candidates for wide-ranging applications, yet their synthesis can be low-yielding, poorly reproducible, and resource-intensive, limiting their use. Here, we explore the use of Non-Thermal Plasma (NTP) as an efficient method for the synthesis of imine macrocycles at the gram scale. NTP-mediated macrocyclisations consistently achieved high yields of up to 97% in reduced reaction times compared to the standard non-plasma method, and were successfully carried out with a range of different aldehyde substrates. Control experiments were performed to explore the origin of the observed improvements. The results indicate that NTP methods could be advantageous for macrocycle synthesis, particularly for substrates that are sensitive to elevated temperature, and other materials formed via imine condensation.

Graphical abstract: High-efficiency non-thermal plasma synthesis of imine macrocycles

Supplementary files

Article information

Article type
Paper
Submitted
01 Feb 2024
Accepted
02 Apr 2024
First published
08 Apr 2024
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2024,9, 1896-1903

High-efficiency non-thermal plasma synthesis of imine macrocycles

P. Roszkowska, A. M. Scholes, J. L. Walsh, T. L. Easun and A. G. Slater, React. Chem. Eng., 2024, 9, 1896 DOI: 10.1039/D4RE00061G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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