Issue 30, 2023

Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Abstract

Glioma is one of the most common malignant tumors with characteristics of strong invasion and high postoperative recurrence rate, which seriously threatens human health. Nanoparticles as an emerging drug delivery system have promoted the development of glioma therapy. However, blocking of nanoparticles by the blood-brain barrier is still serious problem for the use of nanoparticles in glioma therapy. In this context, traditional nanoparticles are dressed with natural cell membranes to prepare biomimetic nanoparticles. Biomimetic nanoparticles show longer blood circulation time, excellent homologous targeting and outstanding immune escape capacity, which significantly improve the accumulation of nanoparticles at the tumor site. The therapeutic effect for glioma has been raised to an advanced level. This review focuses on the preparations and applications of cell membrane-functionalized biomimetic nanoparticles, as while as the advantages and problems of biomimetic nanoparticles in the treatment of glioma. In particular, the approach of using biomimetic nanoparticles to cross the blood-brain barrier is analyzed, in the hope of providing new ideas for further developments in crossing the blood-brain barrier and in glioma therapy.

Graphical abstract: Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Article information

Article type
Review Article
Submitted
22 Mär 2023
Accepted
13 Jun 2023
First published
16 Jun 2023

J. Mater. Chem. B, 2023,11, 7055-7068

Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

G. Zhang, M. Yao, S. Ma, K. Zhang, Y. Wang, Z. Wang, J. Liang, S. Dai, R. Jin and F. Guan, J. Mater. Chem. B, 2023, 11, 7055 DOI: 10.1039/D3TB00605K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements