Issue 38, 2021

A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles

Abstract

In this study, we aimed to achieve an efficient repair of damaged skeletal muscles using polyvinyl alcohol (PVA) soluble microneedle patches (MNP) loaded with carbonized wormwood and prostaglandin E2 (inflammatory factors). The introduction of carbonized wormwood imparted the MNP with near-infrared light heating characteristics that improved the efficiency of prostaglandin E2 delivery while also promoting circulation in the damaged muscle area. Our experimental results showed that, compared with the classical moxibustion treatment, the system could more quickly restore muscle strength and the cross-sectional area of muscle bundle fibers in a mouse model of muscular injury. In addition, it could also successfully induce the proliferation and differentiation of muscle stem cells to effectively repair injured muscle tissues. Above all, this light-controlled photothermal MN (microneedle) drug-delivery system avoided the common problems of traditional moxibustion such as large levels of smoke, slow efficacy and risk of scalding. Collectively, we put forward a safe, accurate and efficient approach for skeletal muscle damage treatment using carbonized wormwood.

Graphical abstract: A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles

Supplementary files

Article information

Article type
Paper
Submitted
20 Mär 2021
Accepted
13 Mai 2021
First published
03 Sep 2021

J. Mater. Chem. B, 2021,9, 8014-8020

A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles

C. Zhang, S. Jia, J. Huang, H. Peng, J. Zhang, L. Liu, W. Zhang, H. Xin and X. Wang, J. Mater. Chem. B, 2021, 9, 8014 DOI: 10.1039/D1TB00610J

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