Issue 5, 2021

Interfacing cells with organic transistors: a review of in vitro and in vivo applications

Abstract

Recently, organic bioelectronics has attracted considerable interest in the scientific community. The impressive growth that it has undergone in the last 10 years has allowed the rise of the completely new field of cellular organic bioelectronics, which has now the chance to compete with consolidated approaches based on devices such as micro-electrode arrays and ISFET-based transducers both in in vitro and in vivo experimental practice. This review focuses on cellular interfaces based on organic active devices and has the intent of highlighting the recent advances and the most innovative approaches to the ongoing and everlasting challenge of interfacing living matter to the “external world” in order to unveil the hidden mechanisms governing its behavior. Device-wise, three different organic structures will be considered in this work, namely the organic electrochemical transistor (OECT), the solution-gated organic transistor (SGOFET – which is presented here in two possible different versions according to the employed active material, namely: the electrolyte-gated organic transistor – EGOFET, and the solution gated graphene transistor – gSGFET), and the organic charge modulated field effect transistor (OCMFET). Application-wise, this work will mainly focus on cellular-based biosensors employed in in vitro and in vivo cellular interfaces, with the aim of offering the reader a comprehensive retrospective of the recent past, an overview of the latest innovations, and a glance at the future prospects of this challenging, yet exciting and still mostly unexplored scientific field.

Graphical abstract: Interfacing cells with organic transistors: a review of in vitro and in vivo applications

Article information

Article type
Tutorial Review
Submitted
05 Okt 2020
Accepted
10 Dez 2020
First published
10 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2021,21, 795-820

Interfacing cells with organic transistors: a review of in vitro and in vivo applications

A. Spanu, L. Martines and A. Bonfiglio, Lab Chip, 2021, 21, 795 DOI: 10.1039/D0LC01007C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements