Issue 3, 2020

Carbon dots for highly effective photodynamic inactivation of multidrug-resistant bacteria

Abstract

For addressing the ever increasing challenge of multidrug-resistant (MDR) bacterial infections, specifically designed and prepared carbon dots (CDots) of small carbon nanoparticles with surface functionalization–passivation by oligomeric polyethylenimine were found to be readily activated by visible light to effectively and efficiently inactivate MDR bacterial strains. The inactivation was evaluated under various combinations of experimental conditions (dot concentrations, light intensities, and treatment times), with the results collectively suggesting CDots as a new class of promising agents for combating MDR bacteria. Mechanistic origins and implications of the observed strong antibacterial actions as relevant to the photoexcited state processes in CDots and the photodynamically induced cellular damages leading to the death of the bacterial cells were explored, with the results discussed.

Graphical abstract: Carbon dots for highly effective photodynamic inactivation of multidrug-resistant bacteria

Supplementary files

Article information

Article type
Communication
Submitted
04 Mär 2020
Accepted
24 Apr 2020
First published
05 Mai 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 321-325

Carbon dots for highly effective photodynamic inactivation of multidrug-resistant bacteria

D. I. Abu Rabe, O. O. Mohammed, X. Dong, A. K. Patel, C. M. Overton, Y. Tang, S. Kathariou, Y. Sun and L. Yang, Mater. Adv., 2020, 1, 321 DOI: 10.1039/D0MA00078G

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