Issue 60, 2019

Multi-component heteroarene couplings via polarity-reversed radical cascades

Abstract

A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C–C as well as C–N, C–P, and C–Rf bond formation.

Graphical abstract: Multi-component heteroarene couplings via polarity-reversed radical cascades

Supplementary files

Article information

Article type
Communication
Submitted
07 Mai 2019
Accepted
21 Mai 2019
First published
21 Mai 2019

Chem. Commun., 2019,55, 8820-8823

Author version available

Multi-component heteroarene couplings via polarity-reversed radical cascades

J. M. Lear, J. Q. Buquoi, X. Gu, K. Pan, D. N. Mustafa and D. A. Nagib, Chem. Commun., 2019, 55, 8820 DOI: 10.1039/C9CC03498F

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