Issue 12, 2019
From the journal:

Chemical Communications

Real-time visualization of autophagy by monitoring the fluctuation of lysosomal pH with a ratiometric two-photon fluorescent probe†

Peng Ning,‡a   Liling Hou,‡a   Yan Feng, ORCID logo *a   Guoyong Xu,b   Yuyuan Bai,a   Haizhu Yua  and  Xiangming Meng ORCID logo *ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Center for Atomic Engineering of Advanced Materials, and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui 230601, China
E-mail: fy70@163.com, mengxm@ahu.edu.cn
Fax: +86 551 63861467
Tel: +86 551 63861467

b Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China

Abstract

A benzimidazole-decorated two-photon fluorescent probe (Lyso-MPCB) based on the p-methoxyphenylacetylene-substituted carbazole was developed for detecting lysosomal pH with a double-channel signal, which can be used to visualize autophagy by real-time imaging the fluctuation of the pH in the lysosomes.

Graphical abstract: Real-time visualization of autophagy by monitoring the fluctuation of lysosomal pH with a ratiometric two-photon fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C8CC09517E
Article type
Communication
Submitted
30 Nov 2018
Accepted
10 Jan 2019
First published
11 Jan 2019

Chem. Commun., 2019,55, 1782-1785

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Real-time visualization of autophagy by monitoring the fluctuation of lysosomal pH with a ratiometric two-photon fluorescent probe

P. Ning, L. Hou, Y. Feng, G. Xu, Y. Bai, H. Yu and X. Meng, Chem. Commun., 2019, 55, 1782 DOI: 10.1039/C8CC09517E

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