Selective fluorogenic imaging of hepatocellular H2S by a galactosyl azidonaphthalimide probe

De-Tai Shi; Dan Zhou; Yi Zang; Jia Li; Guo-Rong Chen; Tony D. James; Xiao-Peng He; He Tian

doi:10.1039/C4CC09771H

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Selective fluorogenic imaging of hepatocellular H₂S by a galactosyl azidonaphthalimide probe†

De-Tai Shi,^a Dan Zhou,^ab Yi Zang,^b Jia Li,*^b Guo-Rong Chen,^a Tony D. James,^c Xiao-Peng He*^a and He Tian^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

^b National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China
E-mail: jli@simm.ac.cn

^c Department of Chemistry, University of Bath, Bath, UK

Abstract

We have developed a galactosyl azidonaphthalimide probe for the selective fluorogenic imaging of hepatocellular H₂S, an important gaseous transmitter produced in the liver.

This article is part of the themed collection: In celebration of Seiji Shinkai's 70th Birthday

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Article information

DOI: https://doi.org/10.1039/C4CC09771H
Article type: Communication
Submitted: 06 Dec 2014
Accepted: 20 Jan 2015
First published: 21 Jan 2015
This article is Open Access

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Chem. Commun., 2015,51, 3653-3655

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Selective fluorogenic imaging of hepatocellular H₂S by a galactosyl azidonaphthalimide probe

D. Shi, D. Zhou, Y. Zang, J. Li, G. Chen, T. D. James, X. He and H. Tian, Chem. Commun., 2015, 51, 3653 DOI: 10.1039/C4CC09771H

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Chemical Communications