Issue 25, 2015

Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(ii) complex that can be photolyzed by visible light

Abstract

We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(II)-dependent peptide nucleases.

Graphical abstract: Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(ii) complex that can be photolyzed by visible light

Supplementary files

Article information

Article type
Communication
Submitted
11 Okt 2014
Accepted
08 Jan 2015
First published
08 Jan 2015

Chem. Commun., 2015,51, 5501-5504

Author version available

Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(II) complex that can be photolyzed by visible light

J. Mosquera, M. I. Sánchez, J. L. Mascareñas and M. Eugenio Vázquez, Chem. Commun., 2015, 51, 5501 DOI: 10.1039/C4CC08049A

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