Functional framework materials for biomedical applications
Ross S. Forgan, Ruxandra Gref and Jianqiang Liu introduce the Journal of Materials Chemistry B themed collection on functional framework materials for biomedical applications.
Magnetic two-dimensional nanocomposites for multimodal antitumor therapy: a recent review
Magnetic 2D nanocomposites exhibit advanced antitumor applications, including magnetically targeted hyperthermia, drug delivery, phototherapy, nanozyme therapy, immunotherapy and multimodal imaging.
A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery
ZIF-8 nanoparticles, with large surface area and pore capacity, can be functionalized for targeted cancer treatment. This enhances chemotherapeutic drug efficacy and potentially improves PD-1 inhibitors’ effectiveness.
Metal–organic framework-based platforms for implantation applications: recent advances and challenges
This review highlights the recent advances of MOFs and their related hybrids in main implant intervention fields, while also discussing their confronting challenges and future perspectives.
The green synthesis and applications of biological metal–organic frameworks for targeted drug delivery and tumor treatments
Application and development of synthesized bio-MOFs via a green approach (solvent-free and solvent-based green syntheses) for targeted drug delivery and tumor treatment.
A review of zeolitic imidazolate frameworks (ZIFs) as electrochemical sensors for important small biomolecules in human body fluids
The emergence of ZIFs-based composite materials as promising candidates for electrochemical sensors of important small biomolecules in human body fluids.
Review Article
Therapy and diagnosis of Alzheimer's disease: from discrete metal complexes to metal–organic frameworks
Critical analysis of discrete metal compounds and metal–organic frameworks (MOFs) as a platform for the treatment and/or diagnosis of Alzheimer's disease.
Metal–organic frameworks (MOFs) as apt luminescent probes for the detection of biochemical analytes
This article reviews the recent developments in the use of MOF materials as probes and biosensing platforms for diverse chemicals (H2O2, metal ions, H2S, GSH, and nucleic acids) in biological cells.
Metal–organic frameworks (MOFs) as effectual diagnostic and therapeutic tools for cancer
Metal–organic frameworks (MOFs) that comprise metal ions combined with assorted organic linkers have been utilized as tools in cancer therapy.
Paper
Long-lasting insecticidal activity in plants driven by chlorogenic acid-loaded metal–organic frameworks
Ti-based metal–organic frameworks in the controlled and efficient release of insecticidal chlorogenic acid: an in vivo study.
Paper
Exceptional stability of ultrasmall cubic copper metal nanoclusters – a molecular dynamics study
The cubic metal nanoclusters, especially the smaller ones, exhibited stability when placed in 4 M [N1114][C1SO3] ionic liquid solution.
A ZIF-8-encapsulated interpenetrated hydrogel/nanofiber composite patch for chronic wound treatment
Designing wound dressings necessitates the crucial considerations of maintaining a moist environment and implementing effective bacterial control.
Silver oxide decorated urchin-like microporous organic polymer composites as versatile antibacterial organic coating materials
Microporous organic polymers (MOPs) and silver oxide (Ag2O) hybrid composites do show good antimicrobial capabilities, making them flexible for a variety of applications.
Copper(II)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm
A maximum GSH-depleting photodynamic nanosystem was developed by loading Cu2+ into porphyrin MOF. Both in vitro and in vivo results indicate MOF@Cu2+ could obliterate biofilm infection and facilitate wound healing with no distinct side effects.
A potent multifunctional ZIF-8 nanoplatform developed for colorectal cancer therapy by triple-delivery of chemo/radio/targeted therapy agents
Background: Multimodal cancer therapy has garnered significant interest due to its ability to target tumor cells from various perspectives.
Dual-mode fluorescence and electrochemiluminescence sensors based on Ru-MOF nanosheets for sensitive detection of apoE genes
A novel FL–ECL dual-mode sensor for apoE gene detection with ruthenium MOF nanosheets exhibits high sensitivity, wide linear ranges, and robust real-world application potential.
Dual photoresponsive & water-triggered nitric oxide releasing materials based on rhodium-based metal–organic polyhedra
Porous materials based on robust rhodium-based metal–organic polyhedra have relevant NO payloads and release them in response to two different stimuli: light and humidity.
All-in-one HN@Cu-MOF nanoparticles with enhanced reactive oxygen species generation and GSH depletion for effective tumor treatment
The multi-functional nanoparticle HN@Cu-MOF integrates PDT/CDT/GT, leading to a significant enhancement in GSH consumption and an elevation in ROS production, initiating the sensitization to PDT and cell apoptosis in the treatment of tumors.
Porphyrin–anthracene covalent organic frameworks for sustainable photosterilization
A porphyrin–anthracene covalent organic framework for continuous release of singlet oxygen through both photosensitization and cycloreversion pathways was constructed for photosterilization and bacterial-infected wound healing.
Exploring the antimicrobial potential of isoniazid loaded Cu-based metal–organic frameworks as a novel strategy for effective killing of Mycobacterium tuberculosis
Synthesis of IITI-3, INH encapsulation within IITI-3, their drug release, anti-mycobacterial activity and the mycobacterial biofilm inhibition phenomenon of INH@IITI-3.
A metal–organic framework complex for enhancing tumor treatments through synergistic effect of chemotherapy and photodynamic therapy
The La-TCPP@DOX@Apt composite nanomaterial not only avoid the side effects caused by high concentration chemotherapeutic drugs, but also can effectively inhibit and kill solid tumors under the synergistic attack of CD and PDT.
Rational design of copper(I)-doped metal–organic frameworks as dual-functional nanocarriers for combined chemo–chemodynamic therapy
A dual-functional nanocarrier was constructed via in situ crystallization with DOX drugs covalently connected to the surface of CuZn-ZIF for combining chemotherapy and chemodynamic therapy.
PEGylation of a shell over core–shell MOFs—a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties
A new strategy of PEGylation over core–shell MOFs of HKUST-1 and Cu-MOF-2 by a solvothermal method.
Gallium-based metal–organic frameworks loaded with antimicrobial peptides for synergistic killing of drug-resistant bacteria
One-step synthesis of gallium-based metal–organic frameworks loaded with antimicrobial peptides at room temperature for synergistic killing of drug-resistant bacteria.
Exploring the potential of iron-based metal–organic frameworks as peroxidase nanozymes for glucose detection with various secondary building units
This study investigated different secondary building units of iron-based metal–organic frameworks and discovered that when combined with an enzyme-encapsulating ZIF-90 PVP MOF, they could be sequentially employed for glucose detection purposes.
Wool keratin/zeolitic imidazolate framework-8 composite shape memory sponge with synergistic hemostatic performance for rapid hemorrhage control
By combining the keratin and ZIF-8 particles, the problems of the poor mechanical properties and lack of antibacterial effect of the keratin sponge was solved. The released by Zn2+ form ZIF-8 acted as crosslinker to form Zn-S with sulfhydryl groups.
Dual ligand-assisted assembly of metal–organic frameworks on upconversion nanoparticles for NIR photodynamic therapy against hypoxic tumors
The dual ligand functionalization of UCNP and MOF assembly on multiple UCNPs to obtain nanohybrid UCMs.
Green synthesis of metal–organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration
The research direction of this manuscript is focused on osteogenesis through zeolitic imidazolate framework-8 (ZIF-8) loaded dexamethasone DEX. It is shown that DEX can induce osteogenic differentiation of rat bone marrow mesenchymal stem cells and promote osteogenesis in vitro and in vivo.
Paper
Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.
A novel PEC and ECL bifunctional aptasensor based on V2CTx MXene-derived MOF embedded with silver nanoparticles for selectively aptasensing miRNA-126
A novel PEC and ECL bifunctional biosensor for the sensitive and selective detection of miRNA-126 based on the AgNPs@V-PMOF Schottky heterojunction was constructed.
Hydrogen-bonded organic framework-stabilized charge transfer cocrystals for NIR-II photothermal cancer therapy
Within hydrogen-bonded organic frameworks (HOFs), the stabilized charge transfer cocrystals, named TQC@PFC-1, exhibit high photothermal conversion efficiency in the NIR II region for photothermal therapy in both in vitro and in vivo settings.
A metal–organic framework-based fluorescence resonance energy transfer nanoprobe for highly selective detection of Staphylococcus Aureus
We report a nanoprobe for highly sensitive detection of S. aureus, relying on a MOF-based FRET process.
Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer
The DOX@7FZ was able to enhance the ROS level in cancer cells via a synergistic effect between apoptosis/ferroptosis synergism.
About this collection
Synthetic porous materials such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) exhibit unique properties, for example, size-controlled synthesis, geometrically and chemically tuneable pore spaces, very high internal molecular storage capacities, and addressable particle surfaces. For these reasons, functional framework materials such as MOFs and COFs have been extensively investigated for a wide range of applications. Furthermore, the ability to judiciously select structural components with both biocompatibility and functionality has led to the study of these materials across all aspects of nanomedicine, from drug delivery to radiotherapies, imaging, theranostics, and beyond. Notable breakthroughs are typically underpinned by fundamental advances in materials synthesis, functionalisation, and characterisation, as well as interdisciplinary approaches examining biocompatibility, imaging methodologies, and biological mechanisms of therapeutic action, ensuring a broad scientific interest.
This collection in Journal of Materials Chemistry B guest edited by Prof. Ross Forgan (University of Glasgow, UK), Dr Ruxandra Gref (Université Paris Saclay, France) and Prof. Jianqiang Liu (Guangdong Medical University, China) covers all aspects of MOF and COF chemistry related to biological applications. The collection will provide a platform to highlight state-of-the-art developments in a rapidly moving field, including but not limited to, drug delivery (from small molecules through peptides and oligonucleotides to large proteins), all aspects of imaging, theranostics, biological sensing, biocompatibility in vitro and in vivo, hybridisation with other nanomaterials, encapsulation of biological entities (from enzymes to viruses and cells), and other emerging technologies. We hope that this themed collection will bring together the state-of-the-art in the field in one place, acting as a valuable resource for those entering the field while highlighting the huge potential of functional framework materials in biomedicine.