Themed collection Wearable and Implantable Sensors
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Emergence of microfluidic wearable technologies
There has been an emerging interest in the development of microfluidic wearable technologies, arising from increasing demands in the areas of healthcare.
Lab Chip, 2016,16, 4082-4090
https://doi.org/10.1039/C6LC00926C
Shape-adaptable biodevices for wearable and implantable applications
Emerging wearable and implantable biodevices with shape-adaptable capabilities have been significantly revolutionizing the diagnosis and treatment of disease.
Lab Chip, 2020,20, 4321-4341
https://doi.org/10.1039/D0LC00569J
Biomedical optical fibers
Tasoglu, Yetisen and co-workers review the emerging medical and health-related applications of optical fibers, illustrating the new wave for the fabrication of implantable devices, wearable sensors, and photodetection and therapy setups.
Lab Chip, 2021,21, 627-640
https://doi.org/10.1039/D0LC01155J
Flexible plastic, paper and textile lab-on-a chip platforms for electrochemical biosensing
Flexible biosensors represent an increasingly important and rapidly developing field of research.
Lab Chip, 2018,18, 1812-1830
https://doi.org/10.1039/C8LC00025E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Wearable sensors: modalities, challenges, and prospects
Non-invasive wearable sensing technology extracts mechanical, electrical, optical, and chemical information from the human body.
Lab Chip, 2018,18, 217-248
https://doi.org/10.1039/C7LC00914C
An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
Lab Chip, 2020,20, 1390-1397
https://doi.org/10.1039/D0LC00021C
An on-demand micro/nano-convertible channel using an elastomeric nanostructure for multi-purpose use
For microfluidic applications, we propose a nanochannel for easy fabrication and integration, which is capable of an easy transition between the 3 regimes on demand. We demonstrated an ionic diode and pre-concentration/sensing of DNA.
Lab Chip, 2019,19, 2958-2965
https://doi.org/10.1039/C8LC00997J
A wearable electrofluidic actuation system
This work presents a wearable electrofluidic actuation system, which exploits the alternating current electrothermal (ACET) effects to engineer biofluid flow profiles on the body.
Lab Chip, 2019,19, 2966-2972
https://doi.org/10.1039/C9LC00454H
Real-time optical fiber sensors based on light diffusing microlens arrays
The applications of optical fibers are impeded in implantable medical diagnostics due to incompatibility with biological tissues, and immune reaction in vivo.
Lab Chip, 2019,19, 2060-2070
https://doi.org/10.1039/C9LC00242A
An autonomous wearable system for diurnal sweat biomarker data acquisition
We present a hybrid-flex wearable system to autonomously analyze sweat—induced at programmable secretion rates—for diurnal biomarker data acquisition.
Lab Chip, 2020,20, 4582-4591
https://doi.org/10.1039/D0LC00820F
Real time chemical and mechanical human motion monitoring with aerogel-based wearable sensors
Wearable bioelectronic systems are one of the most important tools for human health and motion monitoring.
Lab Chip, 2020,20, 2689-2695
https://doi.org/10.1039/D0LC00545B
Skin-interfaced microfluidic devices with one-opening chambers and hydrophobic valves for sweat collection and analysis
Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health.
Lab Chip, 2020,20, 2635-2645
https://doi.org/10.1039/D0LC00400F
SLOCK (sensor for circadian clock): passive sweat-based chronobiology tracker
SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.
Lab Chip, 2020,20, 1947-1960
https://doi.org/10.1039/D0LC00134A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Control of molecular diffusion through nanofluidic channels using electrostatic gating.
Lab Chip, 2020,20, 1562-1576
https://doi.org/10.1039/D0LC00121J
Contact lens-based lysozyme detection in tear using a mobile sensor
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
Lab Chip, 2020,20, 1493-1502
https://doi.org/10.1039/C9LC01039D
Digital microfluidic meter-on-chip
On-chip digital microfluidic flowmetry can be designed and incorporated into standard microfluidic devices for high-precision multiplexed microflow measurements.
Lab Chip, 2020,20, 722-733
https://doi.org/10.1039/C9LC00989B
Liquid metal electrode-enabled flexible microdroplet sensor
A liquid metal-based soft sensor for droplet detection and evaluation in flexible microchannels.
Lab Chip, 2020,20, 496-504
https://doi.org/10.1039/C9LC00995G
Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels
Presented is an ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels.
Lab Chip, 2020,20, 168-174
https://doi.org/10.1039/C9LC00911F
Soft, skin-interfaced microfluidic systems with integrated enzymatic assays for measuring the concentration of ammonia and ethanol in sweat
Soft microfluidics with reference reactions enable quantitative sweat ammonia–ethanol assay.
Lab Chip, 2020,20, 84-92
https://doi.org/10.1039/C9LC01045A
Flow stabilization in wearable microfluidic sensors enables noise suppression
The all-fluidic low-pass filtering feature of dilatometric strain sensors has the potential to suppress physiological noise.
Lab Chip, 2019,19, 3899-3908
https://doi.org/10.1039/C9LC00842J
A versatile, cost-effective, and flexible wearable biosensor for in situ and ex situ sweat analysis, and personalized nutrition assessment
Point-of-care (POC) diagnostics have shown excellent potential in rapid biological analysis and health/disease monitoring.
Lab Chip, 2019,19, 3448-3460
https://doi.org/10.1039/C9LC00734B
A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration
A wearable, multi-modal sensing patch for sweat rate and electrolyte analysis with inbuilt cross-verification schemes to ensure data integrity.
Lab Chip, 2019,19, 3179-3189
https://doi.org/10.1039/C9LC00598F
A rapid and low-cost fabrication and integration scheme to render 3D microfluidic architectures for wearable biofluid sampling, manipulation, and sensing
We devise a simple, scalable, and low-cost “CAD-to-3D Device” fabrication and integration scheme, which renders 3D and complex microfluidic architectures for wearable biofluid sampling, manipulation, and sensing.
Lab Chip, 2019,19, 2844-2853
https://doi.org/10.1039/C9LC00418A
Remotely controlled nanofluidic implantable platform for tunable drug delivery
An implantable nanofluidic device for remote controlled drug delivery.
Lab Chip, 2019,19, 2192-2204
https://doi.org/10.1039/C9LC00394K
Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system
Passive sweat collection and colorimetric analysis.
Lab Chip, 2019,19, 1545-1555
https://doi.org/10.1039/C9LC00103D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Overcoming transport limitations in miniaturized electrophoretic delivery devices
Combining experimental and theoretical approach, we demonstrate practical solutions to limiting currents in capillary-based electrophoretic delivery devices.
Lab Chip, 2019,19, 1427-1435
https://doi.org/10.1039/C9LC00038K
A liquid metal based capacitive soft pressure microsensor
A PDMS-based handy microsensor for on-chip microscale integrable pressure monitoring with high resolution.
Lab Chip, 2019,19, 807-814
https://doi.org/10.1039/C8LC01357H
Digital nanoliter to milliliter flow rate sensor with in vivo demonstration for continuous sweat rate measurement
A digital flowmetry sensor is fabricated with low limit of detection and wide dynamic range, that is suitable for lab-on-chip or wearable sweat sensing systems.
Lab Chip, 2019,19, 178-185
https://doi.org/10.1039/C8LC00968F
Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation
A wearable sweat biosensing device is demonstrated that stimulates sweat and continuously measures sweat ethanol concentrations at 25 s intervals, which is then correlated with blood ethanol during a >3 hour testing phase.
Lab Chip, 2018,18, 3750-3759
https://doi.org/10.1039/C8LC01082J
A flexible enzyme-electrode sensor with cylindrical working electrode modified with a 3D nanostructure for implantable continuous glucose monitoring
A novel flexible enzyme-electrode sensor was fabricated with a big cylindrical working electrode which, cooperating with the surface-modified 3D nanostructure, significantly improved the sensitivity.
Lab Chip, 2018,18, 3570-3577
https://doi.org/10.1039/C8LC00908B
Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring
A passive wearable microfluidic sensor for the 24 hour monitoring of intraocular pressure using a smartphone.
Lab Chip, 2018,18, 3471-3483
https://doi.org/10.1039/C8LC00758F
Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes
Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films.
Lab Chip, 2018,18, 2816-2825
https://doi.org/10.1039/C8LC00186C
A wearable patch for continuous monitoring of sweat electrolytes during exertion
Implementation of wearable sweat sensors for continuous measurement of fluid based biochemical markers is an attractive alternative to common, yet intrusive and invasive, practices such as urine or blood analysis.
Lab Chip, 2018,18, 2632-2641
https://doi.org/10.1039/C8LC00510A
A fluorometric skin-interfaced microfluidic device and smartphone imaging module for in situ quantitative analysis of sweat chemistry
A wearable microfluidic system and smartphone optics module enabled in situ analysis of sweat.
Lab Chip, 2018,18, 2178-2186
https://doi.org/10.1039/C8LC00530C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Wearable tactile sensor based on flexible microfluidics
We developed a wearable tactile sensor using flexible microfluidics. This liquid-based sensor is thin, flexible and sensitive enough to be mounted on the skin or embedded in a fabric glove to detect tactile forces.
Lab Chip, 2016,16, 3244-3250
https://doi.org/10.1039/C6LC00579A
About this collection
A collection of recent reviews and research papers on the topics of wearable and implantable sensors published in Lab on a Chip and curated by the Lab on a Chip Editorial Board.
This topic area is currently the focus of an Editors’ Choice thematic collection in this field, led by the Lab on a Chip Editorial Board. More details about how to submit to the collection can be found at rsc.li/wearable-sensors-blog.