Themed collection Coronavirus collection – Analytical
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An overview of molecular biology and nanotechnology based analytical methods for the detection of SARS-CoV-2: promising biotools for the rapid diagnosis of COVID-19
Molecular biology and nanotechnology based analytical methods have proven to be promising diagnostic tools for the rapid diagnosis of COVID-19.
Analyst, 2021,146, 1489-1513
https://doi.org/10.1039/D0AN01528H
A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic
Active pharmaceutical ingredients (APIs) are increasingly being identified as contaminants of emerging concern (CECs).
Anal. Methods, 2021,13, 575-594
https://doi.org/10.1039/D0AY02098B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Current advances in the detection of COVID-19 and evaluation of the humoral response
SARS-CoV-2 and humoral response determinations to understand and control the spread of COVID-19.
Analyst, 2021,146, 382-402
https://doi.org/10.1039/D0AN01686A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Detection of RNA viruses from influenza and HIV to Ebola and SARS-CoV-2: a review
RNA-based viruses likely make up the highest pandemic threat among all known pathogens in about the last 100 years, since the Spanish Flu of 1918 with 50 M deaths up to COVID-19.
Anal. Methods, 2021,13, 34-55
https://doi.org/10.1039/D0AY01886D
Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes
We introduce a simple, scalable, and portable electrochemical aptamer-based system for detection of the SARS-CoV-2 spike protein in saliva with attomolar sensitivity.
Anal. Methods, 2021,13, 874-883
https://doi.org/10.1039/D1AY00041A
Colorimetric loop-mediated isothermal amplification (LAMP) for cost-effective and quantitative detection of SARS-CoV-2: the change in color in LAMP-based assays quantitatively correlates with viral copy number
Colorimetric LAMP for COVID-19 intensified diagnostics: a simple and quantitative method comparable in diagnostic performance to RT-qPCR.
Anal. Methods, 2021,13, 169-178
https://doi.org/10.1039/D0AY01658F
Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2
Sulfated polysaccharide from sea cucumber (SCSP), fucoidan from brown algae, and iota-carrageenan from red algae show inhibitory activities against SARS-CoV-2.
Food Funct., 2020,11, 7415-7420
https://doi.org/10.1039/D0FO02017F
Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection
Development of an identification methodology with PS-MS as a sensitive and rapid technique to obtain vastly different chemical changes in COVID-19 infection.
Analyst, 2020,145, 5725-5732
https://doi.org/10.1039/D0AN01074J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out
LAMP-based platform for SARS-CoV-2 RNA detection incorporating beads to remove primer-dimers, enhance fluorescent signal and stop the reaction after amplification.
Lab Chip, 2021,21, 2932-2944
https://doi.org/10.1039/D1LC00266J
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2
Autonomous lab-on-paper platform for simple, rapid, low-cost, and multiplex gene diagnosis of SARS-CoV-2 in clinical samples.
Lab Chip, 2021,21, 2730-2737
https://doi.org/10.1039/D1LC00293G
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2
COVID-19 is a new strain of highly contagious coronavirus. Now, an innovative approach to detect it by combining DNA/RNA oligomers as aptamers and a GO coated optical microfiber as a sensor system.
Lab Chip, 2021,21, 2398-2406
https://doi.org/10.1039/D0LC01231A
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need
The latest developments in thin-film-transistor digital-microfluidics (TFT-DMF) are reported, and proof of concept application to molecular diagnostics (e.g. for coronavirus disease, COVID-19) at the point-of-need demonstrated.
Lab Chip, 2021,21, 962-975
https://doi.org/10.1039/D0LC01143F
Rapid molecular diagnostics of COVID-19 by RT-LAMP in a centrifugal polystyrene-toner based microdevice with end-point visual detection
We developed a low-cost molecular test for the diagnosis of COVID-19, in a centrifugal microdevice, based on RT-LAMP assay run at 72 °C for 10 min.
Analyst, 2021,146, 1178-1187
https://doi.org/10.1039/D0AN02066D
A digital protein microarray for COVID-19 cytokine storm monitoring
A digital microfluidic immunoassay platform enables rapid multiplex quantification of proinflammatory cytokines in serum for critically ill COVID-19 patients.
Lab Chip, 2021,21, 331-343
https://doi.org/10.1039/D0LC00678E
Colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a visual diagnostic platform for the detection of the emerging coronavirus SARS-CoV-2
RT-LAMP to detect SARS-CoV-2: in a positive sample, RT-LAMP leads to a color change from pink to yellow.
Analyst, 2021,146, 471-477
https://doi.org/10.1039/D0AN01775B
A high-throughput multiplexed microfluidic device for COVID-19 serology assays
A microfluidic device to quantitate antibody reactivities to SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples.
Lab Chip, 2021,21, 93-104
https://doi.org/10.1039/D0LC01068E
Detection of the SARS-CoV-2 humanized antibody with paper-based ELISA
This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody.
Analyst, 2020,145, 7680-7686
https://doi.org/10.1039/D0AN01609H
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
COVID-19 is a widespread and highly contagious disease in the human population.
Lab Chip, 2020,20, 4255-4261
https://doi.org/10.1039/D0LC00828A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
A modular microarray imaging system for highly specific COVID-19 antibody testing
The TinyArray imager, a robust inexpensive portable imaging device, can detect antibodies against SARS-CoV-2 based on coronavirus antigen microarrays.
Lab Chip, 2020,20, 3302-3309
https://doi.org/10.1039/D0LC00547A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome
An evaluation of a rapid portable gold-nanotechnology measuring SARS-CoV-2 IgM, IgA and IgG antibody response to spike 1 (S1), spike 2 (S) and nucleocapsid (N) antigens using serum from 74 RNA(+) patients and RNA(+) 47 control patients.
Analyst, 2020,145, 5638-5646
https://doi.org/10.1039/D0AN01066A
Development of a lateral flow immunoassay strip for rapid detection of IgG antibody against SARS-CoV-2 virus
Rapid and simple LFIA strips based on Au NPs provide a preliminary test result for physicians to make the correct diagnosis of SARS-CoV-2 infections along with alternative testing methods.
Analyst, 2020,145, 5345-5352
https://doi.org/10.1039/D0AN00629G
In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients
To date, no specific drug has been discovered for the treatment of COVID-19 and hence, patients are in a state of anxiety.
Food Funct., 2020,11, 5565-5572
https://doi.org/10.1039/D0FO00530D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.
Lab Chip, 2020,20, 2075-2085
https://doi.org/10.1039/D0LC00373E
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
Lab Chip, 2020,20, 1621-1627
https://doi.org/10.1039/D0LC00304B
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The polymerase chain reaction (PCR) has unique advantages of sensitivity, specificity and rapidity in pathogen detection, which makes it at the forefront of academia and application in molecular biology diagnosis.
Analyst, 2020,145, 2767-2773
https://doi.org/10.1039/C9AN01894H
Semi-automatic instrumentation for nucleic acid extraction and purification to quantify pathogens on surfaces
A semi-automated detection system compatible with PCR that can detect infectious pathogens on wide surfaces in a short time.
Analyst, 2019,144, 6586-6594
https://doi.org/10.1039/C9AN00896A
About this collection
All articles on coronavirus research published in the Royal Society of Chemistry Analytical Chemistry Journals can be found here, and are freely available to read until 31st December 2021.