Themed collection Analyst Recent Open Access Articles

Single cell metabolomics using mass spectrometry can contribute to understanding biological activities in health and disease.

Protein mass spectrometry (MS) is an indispensable tool to detect molecular signatures that can be associated with cellular dysregulation and disease.

This review summarizes recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells.

This review highlights the considerable advances in the chemical imaging of human fingermarks. Additional information about the donor can be obtained from the chemical composition of latent fingermarks besides the physical pattern, such as the age, gender, medical history and possible drug habits.

Advancements in ion concentration polarization made over the past three years are highlighted.

Biological application of electrochemical hydrogen sulfide sensors.

We present an overview of current isolation, detection, and characterization methods of extracellular vesicles and their applications and limitations as a potential emerging biomarker in cancer management and their clinical implementation.

The analysis of thin films is of central importance for functional materials, including the very large and active field of nanomaterials.

Reviewing latest developments on lab on chips for enhanced control of cells’ experiments.

Recent advances in Au NP based optical sensing systems for various analytes based on absorption, fluorescence and SERS are summarized.

RPA is a versatile complement or replacement of PCR, and now is stepping into practice.

In this review we present the state of the art and the most recent advances in the field of optical sensing with hybrid plasmonic–photonic whispering gallery mode (WGM) resonators.

A critical review on the development of microfluidic tests capable of the high-sensitivity measurement of protein biomarkers at the point-of-care.

This is the first comprehensive review on chemometric techniques used in ion mobility spectrometry data analysis.

Surface-enhanced Raman spectroscopy offers ultra-sensitive vibrational fingerprinting within biological cells.

This review highlights some of the most recent advances in the development of Raman spectroscopy for live cell studies.

Metal nanoclusters (NCs) are emerging as a new class of functional nanomaterials in the area of biological sensing, labelling, imaging and therapy due to their unique physical and chemical properties, such as ultrasmall size, HOMO–LUMO transition, strong luminescence together with good photostability and biocompatibility.

This article reviews a very recent field of noninvasive analysis of turbid media using micro-scale Spatially Offset Raman Spectroscopy – micro-SORS.

Advancement in technologies which can provide highly selective and sensitive multiplex detection of biomarkers is inevitable for accurate disease prognosis, diagnosis, and treatment follow-up.

A redox-sensitive inter-conversion between ascorbic acid (ASC) and its oxidized form dehydroascorbic acid (DHA) in the intracellular environment has been of exceptional interest to recent metabolomics and pharmaceutical research.

The first report on capillary photoionization interfacing a liquid chromatograph and mass spectrometer.

This paper describes the detection of endogenous cyanide using corrin-based CyanoKit technologies in combination with a smartphone readout device.

The first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of methoxphenidine (MXP) and its regioisomers.

A novel analytical approach for the identification/quantification of the reduction products of platinum(IV) complexes is presented.

We describe a simple bulk method to prepare double emulsions for high-throughput analysis and sorting with flow cytometers.

Nanoslits with a depth of ∼10 nm were manufactured on a germanium internal reflection element for attenuated internal reflection infrared spectroscopy.

A quantitative method based on image analysis of multiple color changes in microfluidic paper-based analytical devices using CIE L*a*b* color difference is presented.

A novel labeling strategy – which results in one label per antibody molecule – was used for multiplex and quantitative immuno imaging by use of LA-ICP-MS.

The first combination of a ring-shaped vertically emitting quantum cascade laser (riQCL) with a substrate-integrated hollow waveguide (iHWG) is presented.

Monitoring catalyst performance via substrate-integrated hollow waveguide (iHWGs) assisted infrared spectroscopy.

Using Surface Enhanced Raman Spectroscopy to measure cell death caused by radiation in a 3D model of prostate cancer.

A single Au nanoparticle (NP) with a diameter of 5 nm was transferred to the end of a Si-tip through a picking process, and an Ag shell with a controlled thickness was formed on the Au core.

A multivariate analysis of data from urine with an electronic voltammetric tongue to detect patients with prostate cancer.

The transfer of protons or proton donor/acceptor abilities is an important phenomenon in many biomolecular systems.

The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin F_ab fragment.

A combination of solid phase extraction, para-hydrogen induced hyperpolarization and selective NMR detection allows the quantitative determination of a doping substance at sub-μM concentrations in urine.

A stable isotope approach combined with SERS analysis of bacteria allows clarification of the origin of a pronounced band at 730 cm⁻¹.

The first highly water soluble, blue-luminescent iridium(III) complex for chemiluminescence detection is presented.

A mediatorless sulfide electrochemical sensing platform utilising a novel nanocopper-oxide screen-printed electrodes (CuSPE) is reported for the first time.

An ultrasensitive ratiometric fluorescent sensor made of an N,N-dimethylaminonaphthalene anhydride moiety for detection of aliphatic primary amines is reported.

Acute leukemia is a malignant clonal disease of hematopoietic stem cells with a high prevalence and mortality rate.

Here we demonstrate light mediated heating of nanoparticles confined deep inside mammalian tissue, whilst directly monitoring their temperature non-invasively using a form of deep Raman spectroscopy, T-SESORS.

An in vitro screening platform for high-throughput profiling and comparison of two-photon photodynamic therapy sensitizers was established.

Sensitive CVG-AFS/ICP-MS label-free nucleic acid and protein assays based on a selective cation exchange reaction and simple filtration separation.

A direct and fast method for quantification of illicit drugs in beverages and biological fluids was developed, using dielectric barrier discharge ionization in combination with high-resolution MS.

Highly sensitive and selective trace gas detection based on a novel photo-acoustic laser spectroscopy method.

New aza-BODIPY pH indicators with spectral properties modulated solely by photoinduced electron transfer (PET) are presented.

An ultrasensitive SERS-based cascade amplification bioassay is proposed that couples SERS technology with cascade amplification of the B–S system.

A simple and novel strategy for detection of AA and ALP via controlled generation of Ag NPs and selective recognition.

Possibility to associate gunshot residues with other residues or their original ammunition has been demonstrated using a novel predictive approach.

Raman studies of dynamically expanded cell-free plasma domains in microfluidic blood flow.

A thiocoumarin that exhibits varying fluorescence responses to metal ions in different solvents can be used in a single-probe multiple-solvent array for distinguishing metal ions.

Dual HILIC and RP chromatography coupled to high-resolution mass spectrometry for the simultaneous analysis of metabolites and lipids.

Charge-based biomarker concentration using magnetic beads improves ultrasensitive schistosomiasis diagnostic and eliminates need for well-equipped laboratory in low-resource settings.

Highly specific identification of water-insoluble organic pigments is facilitated by automated matrix-assisted laser desorption/ionization tandem mass spectrometry and data evaluation.

A 3D printed micro-bioreactor and microfluidic chip with integrated screen printed glucose biosensor for online monitoring of glucose to aid micro-bioprocess control.

A validated method for rapid and reliable measurement of five arachidonic acid metabolites in biofluids using supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS).

A highly sensitive interdigitated electrode (IDE) with vertically aligned dense carbon nanotube forests directly grown on conductive supports was demonstrated by combining UV lithography and a low temperature chemical vapor deposition process (470 °C).

Benchtop NMR spectrometers operating with magnetic fields of 1–2 T at sub-ppm resolution coupled with SABRE hyperpolarization show great promise as analytical platforms that can be used outside the traditional laboratory environment.

An Electrochemical Derived Intercalation process is explored as a modification for screen-printed electrodes to improve their electroanalytical outputs.

We have developed a simple method for preparing small-volume droplets for performing digital culture, allowing for the detection of bacteria.

The proposed algorithm minimizes the influence of baseline distortion and exhibits good anti-noise ability and high real-time performance.

Lipid and elemental distributions in chicken phalanx imaged by MALDI MSI and μXRF.

Polar and non-polar lipids analysis in 15 min chromatographic run time was enabled by a novel instrumental setup using orthogonal HILIC and RP separation and effluent combination prior to high-resolution mass spectrometry.

We detail the use of cross-linkable solutions of dextran-methacrylate to form hydrogels capable of collecting amino acids and DNA from fingerprints, while allowing for their increased visualisation at a later stage.

A surface acoustic wave (SAW) induces a bubble in a 3D designed multi-trap polydimethylsiloxane (PDMS) device for the selection, incubation and on-demand release of aqueous droplets from a continuous oil flow.

This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. A model allowing optimal results is described.

A multiple-pass, exonuclease III-mediated target recycling circuit is described for sensitive DNA detection with a shorter assay time.

Imaging of the in situ production of nitric oxide following phagocytosis of Escherichia coli bacteria using a NO nanobiosensor.

Cellulose films as well as chitosan-modified cellulose films of approximately 5 μm thickness, reconstituted from ionic liquid media onto a poly(ethylene-terephthalate) (PET, 6 μm thickness) film with a 5, 10, 20, or 40 μm diameter laser-drilled microhole, show significant current rectification in aqueous NaCl.