In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
This review highlights the strategy of photocatalytic fluoroalkyl radical-induced cyclization for synthesizing 5–7 membered fluorinated heterocycles.
The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.
Three-component reactions enable easy difluorinated-compound synthesis. Advances from 2014–2024 have been categorized as (a) radical, (b) difluorocarbene, (c) nucleophilic or electrophilic fluorine routes.
Recent advances on non-precious metal-catalysed fluorination, difluorimethylation, trifluoromethylation, and perfluoroalkylation of N-heteroarenes is presented.