Introduction of a C6-alkoxy group on the penicillin scaffold can alter the mechanism of SARS-CoV-2 main protease (Mpro) inhibition.
A new method for the synthesis of 1H-1,2,3-triazolium salts from triazenes and simple alkenes has been developed.
Camphene reacts with sulfonamides in the presence of oxidants to give N-sulfonyl derivatives of camphane or isocamphane with or without solvent incorporation depending on the reagent and the ratio of the reactants.
For the first time, cationic linear N-chloramine biocides that do not include 5,5-dimethyl hydantoin scaffolds were synthesized, and their long chain analogues were found to exert greatly elevated biocidal efficacy.
Site-selective oxidation of unprotected saccharides, followed by treatment of the corresponding trityl hydrazone with t-Bu hypochlorite, gives a chloro-azo intermediate that can be substituted to give deoxythio sugars. This allows a protecting group-free synthesis of thioglycosides.