Introduction of a C6-alkoxy group on the penicillin scaffold can alter the mechanism of SARS-CoV-2 main protease (Mpro) inhibition.
A new method for the synthesis of 1H-1,2,3-triazolium salts from triazenes and simple alkenes has been developed.
Camphene reacts with sulfonamides in the presence of oxidants to give N-sulfonyl derivatives of camphane or isocamphane with or without solvent incorporation depending on the reagent and the ratio of the reactants.
Zwitterionic pyridinium N-chloramines were synthesized to find that spacer variations contributed little to biocidal activity enhancement, whereas some linker variations (e.g.15 and 17) resulted in drastically elevated bactericidal efficacy.
For the first time, cationic linear N-chloramine biocides that do not include 5,5-dimethyl hydantoin scaffolds were synthesized, and their long chain analogues were found to exert greatly elevated biocidal efficacy.