New lactose–2-iminothiazolidin-4-one hybrids 7a–h had the multi-target inhibitions for T2DM enzymes. They showed high anti-glycation, antioxidant activities and no-cytotoxic for WI-38 cell. Molecular docking and dynamics studies were applied.
In this paper, an efficient synthesis of 2-iminothiazolidin-4-ones through a copper-catalyzed tandem annulation reaction of alkyl amines, isothiocyanates and diazo acetates is presented.
The reaction of propargylamines with isothiocyanates selectively gives iminothiazolidines, aminothiazolines, or mixed thiazolidine–thioureas under mild conditions. Coordination studies of these compounds with gold and silver have been performed.
The present feature article focuses on recent developments in the realm of photocatalyst-free C–N bond formations, highlighting the innovative approaches that leverage light without relying on traditional photocatalysts.
This review summarises the reactivity and synthetic procedures of aryl and acyl isothiocyanates, a versatile reagent with multiple reactive centres.