The conjugate isothiocyanation of enones with trimethylsilyl isothioyanate provides excellent yields of β-isocyanato ketones under mild conditions, through a thermodynamically-controlled addition of the thiocyanate anion on the protonated enone.
This review highlights recent advances in copper-catalyzed thiocyanation, showcasing copper’s versatility, cost-effectiveness, and efficiency in introducing the SCN− group into diverse organic substrates, thereby enabling the synthesis of sulfur-containing compounds vital to pharmaceuticals and natural products.
A Brønsted acid-catalyzed photoinduced intermolecular alkylative isothiocyanation of conjugated dienes is reported. The optimized method does not require any exogenous photocatalyst or additives.
This review summarises the reactivity and synthetic procedures of aryl and acyl isothiocyanates, a versatile reagent with multiple reactive centres.
The 1,3-thiazole scaffold represents a privileged heterocyclic framework present in a broad spectrum of biologically active molecules and associated with a wide range of pharmacological effects.