This review highlights recent advances in heterogeneous catalytic deuteration using D2O and emerging applications of deuterium labelling, including deuterium metabolic imaging, deuterated luminescent materials, and quantitative mass spectrometry.
Graphical abstract image generated with Copilot.
We present a reductive deuteration system using Mg/CH3OD, which successfully facilitates the conversion of α,β-unsaturated esters, amides, and nitriles to their saturated counterparts.
A highly chemoselective reductive deuteration of thioacids to provide α,α-dideuterio alcohols using SmI2 and D2O as deuterium source.
A molybdenum-mediated reductive deuteration of nitroarenes for the selective synthesis of ortho- and para-deuterated anilines has been developed, using Mo(CO)6 as the reductant and the catalyst and D2O as D-source.