Nicholas S. O'Brien, Jayne Gilbert, Adam McCluskey and Jennette A. Sakoff
RSC Med. Chem., 2024,15, 1686-1708
Abstract
Simple synthesis, binds and inhibits tubulin, and potent broad-spectrum cytotoxicity.
Arun K. Ghosh, Daniel Lee, Ashish Sharma, Megan E. Johnson, Ajay K. Ghosh, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Shin-ichiro Hattori, Irene T. Weber and Hiroaki Mitsuya
Org. Biomol. Chem., 2024,22, 7354-7372
From themed collection:
Celebrating the 100th birthday of Professor Sukh Dev
Abstract
A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed, synthesized and evaluated.
Jufeng Sun, Jennifer R. Baker, Cecilia C. Russell, Hong N. T. Pham, Chloe D. Goldsmith, Peter J. Cossar, Jennette A. Sakoff, Christopher J. Scarlett and Adam McCluskey
RSC Med. Chem., 2023,14, 2246-2267
Abstract
Tight binding in the S100A2–p53 interaction groove = sub micromolar potencies against pancreatic cancer cell lines.
Abhijit Gogoi, Subhamoy Mukhopadhyay, Raju Chouhan and Sajal Kumar Das
Org. Biomol. Chem., 2024,22, 353-363
Abstract
A one-pot, transition-metal-free, regioselective synthesis of spirooxindole derivatives containing benzimidazole-fused 1,4-benzoxazepine and benzosultam scaffolds has been developed.
Vasco Cachatra, Alice Martins, Maria Conceição Oliveira, Maria Cristina Oliveira, Lurdes Gano, António Paulo, Óscar López, José G. Fernández-Bolaños, Marialessandra Contino, Nicola Antonio Colabufo, David Evans, Teresa Man and Amélia Pilar Rauter
Org. Biomol. Chem., 2025,23, 3845-3859
From themed collection:
Articles behind our 2025 journal covers
Abstract
A multidisciplinary study of purine nucleoside selective BuChE inhibitors, covering docking, synthesis, biological evaluation and cytotoxic assays.