The continuous flow synthesis of a series of pyrazinamide derivatives catalyzed by Lipozyme® TL IM was successfully achieved with good scalability. A continuous production of pyrazinamide derivatives was first performed coupled with enzymes.
DFT studies were carried out to understand the adsorption mechanism of twelve drug molecules on the B12N12 and Al12N12 nanocages.
Advancements in the design and development of pyrazoline-based antimycobacterial agents (1975–2025 & beyond).
We present a preparation of complex dienes and eneynes by Rh-catalyzed hydroarylation of internal alkynes and Pd-catalyzed olefinic C–H alkenylation, alkynylation and allylation, enabled by the chelation assistance of pyrazinamide or picolinamide.
This review highlights the recent synthetic developments of benzothiazole based anti-tubercular compounds. Structure activity relationship of benzothiazole derivatives with molecular docking studies of selected compounds have been discussed against the target DprE1.