Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

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Food Funct., 2024, 15, 10746
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Biomimetic mineralization with enhanced hydrogen-bond interactions for protein stabilization

Yihao Cui, Shuling Tang, Tianren Liu, Chen Luo and Xiaoyu Wang

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Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics

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RSC Pharm., 2025
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Innovative Formulation Strategies for Biosimilars: Trends Focused on Buffer-Free Systems, Safety, Regulatory Alignment, and Intellectual Property Challenges

Tomas Gabriel Bas

Pharmaceuticals, 2025, 18, 908
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Revisiting the significance of natural protease inhibitors: A comprehensive review

Dhiman Chandra Paul and Minakshi Bhattacharjee

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Controllable synthesis of hydrogen-bonded organic framework encapsulated enzyme for continuous production of chiral hydroxybutyric acid in a two-stage cascade microreactor

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Chinese Journal of Chemical Engineering, 2025, 77, 175
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Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

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Exploring Protein-Based Carriers in Drug Delivery: A Review

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Strategies for Non-Covalent Attachment of Antibodies to PEGylated Nanoparticles for Targeted Drug Delivery

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Enhancing Functional Protein Design Using Heuristic Optimization and Deep Learning for Anti‐Inflammatory and Gene Therapy Applications

Ayşenur Soytürk Patat and Özkan Ufuk Nalbantoğlu

Proteins, 2025, 93, 1238
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AggNet: Advancing protein aggregation analysis through deep learning and protein language model

Wenjia He, Xiaopeng Xu, Haoyang Li, Juexiao Zhou and Xin Gao

Protein Science, 2025, 34
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Advancing Cu/Zn Superoxide Dismutase (SOD1) production in Pichia pastoris : challenges, strategies, current research status, and future directions

Abdulqader Al-Adeeb, Sahibzada Muhammad Aqeel, Hend Sadeq Aljaberi, Qiuya Gu, Shuoqi Jiang, Siqi Ma and Xiaobin Yu

Preparative Biochemistry & Biotechnology, 2025, 1
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Modern Approaches to Protein Constructions: A Comprehensive Review of Computational Tools and Databases for De Novo Protein Design and Engineering

Md. Mojnu Mia, Habiba Sultana, Md. Al Amin, Md. Sakhawat Hossain, Hasan Imam, A. K. M. Mohiuddin and Shahin Mahmud

Engineering Reports, 2025, 7
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Study on the development of nanoparticles based on levan for oral insulin delivery

Desy Kurniawati, Neng Fisheri Kurniati, Enny Ratnaningsih and Rukman Hertadi

Biomed. Mater., 2025, 20, 025028
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Fabricating N-Cadherin Mimetic Peptide-Based Diverse Self-Assembled Hydrogels in the Presence of Biologically Relevant Cations

Sweta Mohanty and Sangita Roy

Biomacromolecules, 2025, 26, 2238
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Biophysical insights into pH-induced structural dynamics of recombinant interferon β-1b: Aggregation under acidic conditions

Ayesha Aiman, Faiza Iram, Danish Alam, Seemi Farhat Basir, Luqman Ahmad Khan, Mohammad Shahid and Asimul Islam

International Journal of Biological Macromolecules, 2025, 318, 145128
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Pre-Concentration Freezing Alters the Composition of Mesenchymal Stem/Stromal Cell-Conditioned Medium

Francesca Cadelano, Chiara Giannasi, Alice Gualerzi, Martina Gerli, Stefania Niada, Elena Della Morte and Anna Teresa Brini

Biology, 2025, 14, 181
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Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han and Qiang Huang

Advanced Science, 2025, 12
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Improved Prediction of Stabilizing Mutations in Proteins by Incorporation of Mutational Effects on Ligand Binding

Srivarshini Ganesan, Nidhi Mittal, Akash Bhat, Rachana S. Adiga, Ananthakrishnan Ganesan, Deepesh Nagarajan and Raghavan Varadarajan

Proteins, 2025, 93, 384
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Optimization of continuous spin-freeze-drying: The role of spin-freezing on quality attributes and drying efficiency of a model peptide formulation

Zarah Schaal, Pieter-Jan Van Bockstal, Joris Lammens, Julian H. Lenger, Adrian P. Funke, Stefan C. Schneid, Hristo L. Svilenov and Thomas De Beer

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Biophysical Insights into the Interaction of Zwitterionic Surfactant (Sulfobetaine 10) with Aggregation-Prone Protein

Abdulaziz Alamri, Ajamaluddin Malik, Javed Masood Khan, Abdullah S. Alhomida, Md. Tabish Rehman and Mohammad Shamsul Ola

J. Oleo Sci., 2025, 74, 599
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The effect of extremolytes ectoine and hydroxyectoine on the heat-induced protein aggregation: The case of growth hormone

Rūta Gruškienė and Jolanta Sereikaitė

Biochimie, 2025, 229, 42
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Stability of Protein Pharmaceuticals: Recent Advances

Mark Cornell Manning, Ryan E. Holcomb, Robert W. Payne, Joshua M. Stillahn, Brian D. Connolly, Derrick S. Katayama, Hongcheng Liu, James E. Matsuura, Brian M. Murphy, Charles S. Henry and Daan J. A. Crommelin

Pharm Res, 2024, 41, 1301
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Polypeptide-protein conjugation: A new paradigm for therapeutic protein delivery

Xiao Zhang, Shiwei Fu, Bowen Zhao, Yilin Liu, Ronald S. Seruya and Fuwu Zhang

Journal of Controlled Release, 2025, 384, 113953
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Exploring Protein Aggregation in Biological Products: From Mechanistic Understanding to Practical Solutions

Satish Rojekar, Amol D. Gholap, Krishna Jadhav, Ganesh Shevalkar, Vrashabh V. Sugandhi, Rohan Pai, Kinjal Parikh, Mahendra Kumar Prajapati, Nimeet Desai, Lalitkumar K. Vora, Rahul G. Ingle and Keshav Raj Paudel

AAPS PharmSciTech, 2025, 26
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Stabilising proteins in solution using affordable and readily available small molecules

Sandrine Bakam Tchiakam, Sarah L. Berger, June Southall, Helen Walden and Mads Gabrielsen

Biophys Rev, 2025
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Application of lyophilization in pharmaceutical injectable formulations: An industry and regulatory perspective

Samarth Kumar, Sachin N. Sanap, Milan Vasoya, Mayank Handa, Prachi Pandey, Ajay Khopade and Krutika K. Sawant

Journal of Drug Delivery Science and Technology, 2024, 100, 106089
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Recombinant Expression of Single-Chain Variable Fragment Antibody: A Comparative Study of Growth Medium Effects

Mobina Mansourian, Atieh Hashemi and Majid Basafa

Jundishapur J Nat Pharm Prod, 2025, 20
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The impact of process parameters on the lyophilized porous micro-structure: A case study of dextran

Andraž Košir, Fiora Artusio, Leif-Thore Deck, Roberto Pisano and Marco Mazzotti

Journal of Pharmaceutical Sciences, 2025, 114, 1434
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Evaluating the storage stability of a Plasmodium vivax circumsporozoite protein vaccine candidate

Janaína Tenorio Novais, Rodolfo Ferreira Marques, Alba Marina Gimenez and Irene Silva Soares

Process Biochemistry, 2025, 151, 126
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Leveraging a large language model to predict protein phase transition: A physical, multiscale, and interpretable approach

Mor Frank, Pengyu Ni, Matthew Jensen and Mark B. Gerstein

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
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Integrating Computational Design and Experimental Approaches for Next-Generation Biologics

Ahrum Son, Jongham Park, Woojin Kim, Wonseok Lee, Yoonki Yoon, Jaeho Ji and Hyunsoo Kim

Biomolecules, 2024, 14, 1073
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Molecular Modelling in Bioactive Peptide Discovery and Characterisation

Clement Agoni, Raúl Fernández-Díaz, Patrick Brendan Timmons, Alessandro Adelfio, Hansel Gómez and Denis C. Shields

Biomolecules, 2025, 15, 524
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Recent research on the druggability properties of chemical modification of endogenous substances

Tao Yuan, Sulong Xiao and Demin Zhou

Sci. Sin.-Chim, 2025, 55, 2452
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Adverse Impacts of PEGylated Protein Therapeutics: A Targeted Literature Review

Chae Sung Lee, Yogesh Kulkarni, Vicki Pierre, Manish Maski and Christoph Wanner

BioDrugs, 2024, 38, 795
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Protein Engineering Paving the Way for Next-Generation Therapies in Cancer

Zahra Naderiyan and Alireza Shoari

IJTM, 2025, 5, 28
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Citrate-Assisted Regulation of Protein Stability and Secretability from Synthetic Amyloids

Hèctor López-Laguna, Marianna T.P. Favaro, Sara Chellou-Bakkali, Eric Voltà-Durán, Eloi Parladé, Julieta Sánchez, José Luis Corchero, Ugutz Unzueta, Antonio Villaverde and Esther Vázquez

ACS Appl. Mater. Interfaces, 2025, 17, 14940
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A review on sustainable non-thermal approaches for pea protein: Pre-treatment, extraction, modification, and applications

Nikhil Dnyaneshwar Patil, Ankur Kumar, Aarti Bains, Mohammad Fareed, Sanju Bala Dhull, Rupak Nagraik and Prince Chawla

Food Chemistry: X, 2025, 29, 102608
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Biologics, theranostics, and personalized medicine in drug delivery systems

Matteo Puccetti, Marilena Pariano, Aurélie Schoubben, Stefano Giovagnoli and Maurizio Ricci

Pharmacological Research, 2024, 201, 107086
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Thermal Stabilisation of Lysozyme through Ensilication

Reveng A. Abdulkareem, Aswin Doekhie, Nikoletta Fotaki, Francoise Koumanov, Charlotte A. Dodson and Asel Sartbaeva

Molecules, 2024, 29, 4207
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Investigating urea-induced denaturation of human aurora kinase B: Integrated spectroscopic and computational approaches

Saba Noor, Yuanyuan Wang, Safikur Rahman, Faez Iqbal Khan, Anam Ashraf, Ayesha Aiman, Sana Saifi, Mohini Singla, Afzal Hussain and Md. Imtaiyaz Hassan

Journal of Molecular Structure, 2025, 1343, 142724
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Analysis of aggregation profile of glucagon using SEC-HPLC and FFF-MALS methods

Zhongli Bao, Ya-Chi Cheng, Mary Ziping Luo, Jack Yongfeng Zhang and Swaroop Kumar Pandey

PLoS ONE, 2024, 19, e0304086
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A comprehensive review on integration of cellular metabolic engineering and cell-free systems for microbial platforms

Arunangshu Das, Anita Verma and Naba Hazarika

Process Biochemistry, 2025, 149, 222
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A Review on the Stability Challenges of Advanced Biologic Therapeutics

Sruthi Sarvepalli, Shashank Reddy Pasika, Vartika Verma, Anusha Thumma, Sandeep Bolla, Pavan Kumar Nukala, Arun Butreddy and Pradeep Kumar Bolla

Pharmaceutics, 2025, 17, 550
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Evaluation of XSB-001 (Ranibizumab Biosimilar) Physicochemical and Biological Stability in Prepared Syringes for Intravitreal Injection

Robert Björnestedt, Sean Waters, Aušrinė Paišytė, Fabricio Furlan and Christian Wanner

Adv Ther, 2025
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A review of innovative extraction technologies for protein recovery from plant-based by-products: A step toward zero-waste processing

Eman Shawky, Wei Zhu and Jingkui Tian

International Journal of Biological Macromolecules, 2025, 315, 144301
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RNA–lipid nanoparticles for acute critical illnesses

Serena Omo-Lamai, Marco E. Zamora, Bernhard K. Mueller, Jessica C. Casciano and Jacob S. Brenner

Nat Rev Bioeng, 2025
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