Synthesis of a half-sandwich complex of ruthenium(ii) with a nonsymmetric bis-nitrogen donor ligand: biological investigations

Sana Yarahmadi, Elham Jokar, Zahra Shamsi, Dalia Nahieh, Mehrnoosh Moosavi, Masood Fereidoonnezhad and Hamid R. Shahsavari

New J. Chem., 2023, 47, 6266
DOI: 10.1039/D2NJ06075B

Non-mutagenic Ru(ii)–phosphine-based complexes induce mitochondria-mediated apoptosis in breast cancer cells: from 2D to 3D investigations

Marcos V. Palmeira-Mello, Tamara Teixeira, Analu R. Costa, Aline Maria Machado, Rone A. De Grandis, Leticia P. de Oliveira, Carlos A. F. Moraes, João H. de Araujo-Neto, Victor M. Deflon, Adriano D. Andricopulo, Javier Ellena, Heloisa S. Selistre-de-Araújo, Fillipe V. Rocha and Alzir A. Batista

Inorg. Chem. Front., 2025, 12, 4812
DOI: 10.1039/D5QI00546A

Exploring the cytotoxicity of dinuclear Ru(ii) p-cymene complexes appended N,N′-bis(4-substituted benzoyl)hydrazines: insights into the mechanism of apoptotic cell death

Arunachalam Abirami, Umapathy Devan, Rengan Ramesh, Arockiam Antony Joseph Velanganni and Jan Grzegorz Małecki

Dalton Trans., 2024, 53, 5167
DOI: 10.1039/D3DT04234K

Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells

Nurul Akmarina Mohd Abdul Kamal, Emilia Abdulmalek, Sharida Fakurazi, Kyle E. Cordova and Mohd Basyaruddin Abdul Rahman

Dalton Trans., 2021, 50, 2375
DOI: 10.1039/D1DT00116G

Exploring the potential of ruthenium(ii)–phosphine–mercapto complexes as new anticancer agents

Marcos V. Palmeira-Mello, Analu R. Costa, Leticia P. de Oliveira, Olivier Blacque, Gilles Gasser and Alzir A. Batista

Dalton Trans., 2024, 53, 10947
DOI: 10.1039/D4DT01191K

New ruthenium(ii) complexes with cyclic thio- and semicarbazone: evaluation of cytotoxicity and effects on cell migration and apoptosis of lung cancer cells

Yasmim G. Gonçalves, Amanda B. Becceneri, Angelica E. Graminha, Victor M. Miranda, Rafaella R. Rios, Francisco Rinaldi-Neto, Mônica S. Costa, Ana C. R. Gonçalves, Victor M. Deflon, Kelly A. G. Yoneyama, Pedro I. S. Maia, Eduardo F. Franca, Márcia R. Cominetti, Roberto S. Silva and Gustavo Von Poelhsitz

Dalton Trans., 2023, 52, 9590
DOI: 10.1039/D3DT00750B

Target based chemotherapeutic advancement of ruthenium complexes

Pragti, Bidyut Kumar Kundu and Suman Mukhopadhyay

Coordination Chemistry Reviews, 2021, 448, 214169
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Ru(II)-Based Amino Acid Complexes Show Promise for Leukemia Treatment: Cytotoxicity and Some Light on their Mechanism of Action

Aliny Pereira de Lima, Marcio Aurélio Pinheiro Almeida, Francyelli Mello-Andrade, Flávia de Castro Pereira, Wanessa Carvalho Pires, Davi Carvalho Abreu, Vivianne de Souza Velozo-Sá, Alzir Azevedo Batista and Elisângela de Paula Silveira-Lacerda

Biol Trace Elem Res, 2020, 197, 123
DOI: 10.1007/s12011-019-01976-0

Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug

Katia M. Oliveira, João Honorato, Felipe C. Demidoff, Mario S. Schultz, Chaquip D. Netto, Marcia R. Cominetti, Rodrigo S. Correa and Alzir A. Batista

Journal of Inorganic Biochemistry, 2021, 214, 111289
DOI: 10.1016/j.jinorgbio.2020.111289

Ruthenium complexes show promise when submitted to toxicological safety tests using alternative methodologies

Thallita Monteiro Teixeira, Isabela Gasparini Arraes, Davi Carvalho Abreu, Katia M. Oliveira, Rodrigo S. Correa, Alzir A. Batista, Thomas Braunbeck and Elisaângela de Paula Silveira Lacerda

European Journal of Medicinal Chemistry, 2021, 216, 113262
DOI: 10.1016/j.ejmech.2021.113262

Ruthenium (II)/allopurinol complex inhibits breast cancer progression via multiple targets

Ingrid O. Travassos, Francyelli Mello-Andrade, Raíssa P. Caldeira, Wanessa C. Pires, Paula F. F. da Silva, Rodrigo S. Correa, Tamara Teixeira, Alisson Martins-Oliveira, Alzir. A. Batista and Elisângela P. de Silveira-Lacerda

J Biol Inorg Chem, 2021, 26, 385
DOI: 10.1007/s00775-021-01862-y

Synthesis, characterization and antitumor mechanism investigation of ruthenium(II) polypyridyl complexes with artesunate moiety

Bi-Chun Chen, Jun-Jian Lu, Ning Jiang, Xiu-Rong Ma, Rong-Tao Li and Rui-Rong Ye

J Biol Inorg Chem, 2021, 26, 909
DOI: 10.1007/s00775-021-01901-8

Cytotoxic Ruthenium(II)‐Diphosphine Complexes Affect the Mitochondrial Respiration of Lung Cancer Cells

Marcos V. Palmeira‐Mello, Pierre Mesdom, Pierre Burckel, Samia Hidalgo, Olivier Blacque, Gilles Gasser and Alzir A. Batista

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400734

Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy

Nur Aininie Yusoh, Paul R. Tiley, Steffan D. James, Siti Norain Harun, Jim A. Thomas, Norazalina Saad, Ling-Wei Hii, Suet Lin Chia, Martin R. Gill and Haslina Ahmad

J. Med. Chem., 2023, 66, 6922
DOI: 10.1021/acs.jmedchem.3c00322

Lysosome-targeted ruthenium(II) complexes induce both apoptosis and autophagy in HeLa cells

Nan-Lian Pan, Jia-Xin Liao, Min-Ying Huang, Yu-Qing Zhang, Jia-Xi Chen, Ze-Wei Zhang, Zhi-Xin Yang, Xiong-En Long, Xing-Tao Wu and Jing Sun

Journal of Inorganic Biochemistry, 2022, 229, 111729
DOI: 10.1016/j.jinorgbio.2022.111729

Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands

Tamires D. de Oliveira, Gabriel H. Ribeiro, João Honorato, Celisnolia M. Leite, Aline Caroline da S. Santos, Elis D. Silva, Valéria Rêgo A. Pereira, Ana M. Plutín, Márcia R. Cominetti, Eduardo E. Castellano and Alzir A. Batista

Journal of Inorganic Biochemistry, 2022, 234, 111906
DOI: 10.1016/j.jinorgbio.2022.111906

Ruthenium(II) complex with 2-mercaptothiazoline ligand induces selective cytotoxicity involving DNA damage and apoptosis in melanoma cells

Matheus Reis Santos de Melo, Arthur Barcelos Ribeiro, Gabriela Fernandes, Iara Silva Squarisi, Marcela de Melo Junqueira, Alzir Azevedo Batista, Monize Martins da Silva and Denise Crispim Tavares

J Biol Inorg Chem, 2024, 29, 159
DOI: 10.1007/s00775-023-02036-8

Synthesis, characterization and incorporation of two phosphine-based ruthenium(II) complexes into lipid nanocarriers as potential antimicrobial agents

Francisco W.P. Santana, Antonio C. de S. Silva, Alejandro Pedro Ayala, Ellen A. Malveira, Eduardo H.S. Sousa, Edson H. Teixeira, Mayron A. Vasconcelos, Luiz G.F. Lopes and Alda K.M. Holanda

Polyhedron, 2025, 267, 117340
DOI: 10.1016/j.poly.2024.117340

Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo

Monize M. da Silva, Gabriel H. Ribeiro, Mariana S. de Camargo, Antônio G. Ferreira, Leandro Ribeiro, Marília I. F. Barbosa, Victor M. Deflon, Silvia Castelli, Alessandro Desideri, Rodrigo S. Corrêa, Arthur B. Ribeiro, Heloiza D. Nicolella, Saulo D. Ozelin, Denise C. Tavares and Alzir A. Batista

Inorg. Chem., 2021, 60, 14174
DOI: 10.1021/acs.inorgchem.1c01539

Zebrafish as an Emerging Model System in the Global South: Two Decades of Research in Brazil

Nicholas Silvestre de Souza Trigueiro, Aryelle Canedo, Daniel Lôbo de Siqueira Braga, Ana Carolina Luchiari and Thiago Lopes Rocha

Zebrafish, 2020, 17, 412
DOI: 10.1089/zeb.2020.1930

Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and their anti-cancer properties

Xiaopeng Zhu, Zhipeng Li, Xiaoxi Ji, Qing Chen, Shuangyan Wu, Enjun Gao and Mingchang Zhu

Journal of Inorganic Biochemistry, 2021, 222, 111505
DOI: 10.1016/j.jinorgbio.2021.111505

Exploring the Potential of Metallodrugs as Chemotherapeutics for Triple Negative Breast Cancer

Nazia Nayeem and Maria Contel

Chemistry A European J, 2021, 27, 8891
DOI: 10.1002/chem.202100438

Ru(II) complexes containing uracil nucleobase analogs with cytotoxicity against tumor cells

Rodrigo S. Correa, Larissa M. Bomfim, Katia M. Oliveira, Diogo R.M. Moreira, Milena B.P. Soares, Javier Ellena, Daniel P. Bezerra and Alzir A. Batista

Journal of Inorganic Biochemistry, 2019, 198, 110751
DOI: 10.1016/j.jinorgbio.2019.110751

Cytotoxic activity of Ru(II)/DPEPhos/N,S-mercapto complexes (DPEPhos -[(2-diphenylphosphino)phenyl]ether)

Gregory F. Grawe, Katia M. Oliveira, Celisnolia M. Leite, Tamires D. de Oliveira, Analu R. Costa, Carlos A.F. Moraes, João Honorato, Marcia R. Cominetti, Eduardo E. Castellano, Rodrigo S. Correa, Sérgio P. Machado and Alzir A. Batista

Journal of Inorganic Biochemistry, 2023, 244, 112204
DOI: 10.1016/j.jinorgbio.2023.112204

Gallium and indium complexes with isoniazid-derived ligands: Interaction with biomolecules and biological activity against cancer cells and Mycobacterium tuberculosis

Renan C.F. Leitao, Francisco Silva, Gabriel H. Ribeiro, Isabel C. Santos, Joana F. Guerreiro, Filipa Mendes, Alzir A. Batista, Fernando R. Pavan, Pedro Ivo da S. Maia, António Paulo and Victor M. Deflon

Journal of Inorganic Biochemistry, 2023, 240, 112091
DOI: 10.1016/j.jinorgbio.2022.112091

Three Ru(II) complexes modulate the antioxidant transcription factor Nrf2 to overcome cisplatin resistance

Lanmei Chen, Hong Tang, Tianling Hu, Jie Wang, Qianqian Ouyang, Xufeng Zhu, Rui Wang, Wenyong Huang, Zunnan Huang and Jincan Chen

Journal of Inorganic Biochemistry, 2024, 259, 112666
DOI: 10.1016/j.jinorgbio.2024.112666

Ru(II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

Francyelli Mello-Andrade, Adriana P.M. Guedes, Wanessa C. Pires, Vivianne S. Velozo-Sá, Kezia A. Delmond, Davi Mendes, Matheus S. Molina, Larissa Matuda, Maria Alice Montes de Sousa, Paulo Melo-Reis, Clever C. Gomes, Carlos Henrique Castro, Márcio Aurélio P. Almeida, Carlos F.M. Menck, Alzir A. Batista, Ravshan Burikhanov, Vivek M. Rangnekar and Elisângela Silveira-Lacerda

Journal of Inorganic Biochemistry, 2022, 226, 111625
DOI: 10.1016/j.jinorgbio.2021.111625

Scavenging capacity and cytotoxicity of new Ru(II)-diphosphine/α-amino acid complexes

Vivianne S. Velozo-Sa, Regina M.M. Oliveira, Celisnolia M. Leite, Marcia R. Cominetti, Isabely M.M. Barbosa, Fabrício L.S. Silva, Natália Martins Feitosa, Mario S. Schultz and Alzir A. Batista

Polyhedron, 2021, 201, 115169
DOI: 10.1016/j.poly.2021.115169

“Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

João Honorato de Araujo-Neto, Adriana P. M. Guedes, Celisnolia M. Leite, Carlos André F. Moraes, Andressa L. Santos, Rafaella da S. Brito, Thiago L. Rocha, Francyelli Mello-Andrade, Javier Ellena and Alzir A. Batista

Inorg. Chem., 2023, 62, 6955
DOI: 10.1021/acs.inorgchem.3c00183

Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes

Shuting Li, Chenglan Jiang, Jingwen Tan, Qian Zhou, Jinyao Yin and Yuefeng He

Environ Sci Pollut Res, 2022, 29, 2728
DOI: 10.1007/s11356-021-15891-2

Dual-Action Ru(II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation

Nicholas P. Toupin, Sandeep Nadella, Sean J. Steinke, Claudia Turro and Jeremy J. Kodanko

Inorg. Chem., 2020, 59, 3919
DOI: 10.1021/acs.inorgchem.9b03585

Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells

Nur Aininie Yusoh, Suet Lin Chia, Norazalina Saad, Haslina Ahmad and Martin R. Gill

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-28454-x

Synthesis, characterization, crystal structures, and toxicity studies of nitro-lawsone, its oxime derivative, and Cu(II) complexes

Manisha Gaikwad, Sunita Salunke-Gawali, Vivek Mokashi, Sukanta Mondal, Ray J. Butcher and Bharathi Prakash

Journal of Molecular Structure, 2025, 1337, 142195
DOI: 10.1016/j.molstruc.2025.142195

ZIF-90 nanoparticles modified with a homing peptide for targeted delivery of cisplatin

Adamu Abubakar, Emilia Abdulmalek, Wan Norhamidah Wan Ibrahim, Kyle E. Cordova and Mohd Basyaruddin Abdul Rahman

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.1076350

Ruthenium(II)-mercapto complexes induce cell damage via apoptosis pathway on ovarian cancer cells

Marcos V. Palmeira-Mello, Tamara Teixeira, Matheus Reis Santos de Melo, Heloiza Diniz Nicolella, Jocely L. Dutra, Marcia R. Cominetti, Fillipe Vieira Rocha, Denise Crispim Tavares and Alzir A. Batista

Journal of Inorganic Biochemistry, 2025, 265, 112819
DOI: 10.1016/j.jinorgbio.2024.112819

Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling

Jincan Chen, Yuanyuan Deng, Jie Wang, Suxiang Chen, Fa Peng, Xuerong He, Meijun Liu, Hui Luo, Jingjing Zhang and Lanmei Chen

J Biol Inorg Chem, 2021, 26, 793
DOI: 10.1007/s00775-021-01894-4

Increasing Anticancer Activity with Phosphine Ligation in Zwitterionic Half-Sandwich Iridium(III), Rhodium(III), and Ruthenium(II) Complexes

Xueyan Hu, Lihua Guo, Mengqi Liu, Qiuya Zhang, Yuwen Gong, Mengru Sun, Shenghan Feng, Youzhi Xu, Yiming Liu and Zhe Liu

Inorg. Chem., 2022, 61, 20008
DOI: 10.1021/acs.inorgchem.2c03279

Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction

Gabriel H. Ribeiro, Adriana P. M. Guedes, Tamires D. de Oliveira, Camila R. S. T. b. de Correia, Legna Colina-Vegas, Mauro A. Lima, Joaquim A. Nóbrega, Márcia R. Cominetti, Fillipe V. Rocha, Antônio G. Ferreira, Eduardo E. Castellano, Felipe R. Teixeira and Alzir A. Batista

Inorg. Chem., 2020, 59, 15004
DOI: 10.1021/acs.inorgchem.0c01835