Issue 14, 2021

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

Abstract

A series of three-dimensional Ln-based coordination frameworks were designed and synthesized. After nanolization, they show great potential as efficient and low toxic X-ray responsive radiosensitizers for the treatment of cervical cancer. The experimental data showed that these Ln-based nanoframeworks induced G0/G1 arrest mainly through the increase of the intracellular ROS level.

Graphical abstract: Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

Supplementary files

Article information

Article type
Research Article
Submitted
04 Apr 2021
Accepted
10 Mai 2021
First published
14 Mai 2021

Inorg. Chem. Front., 2021,8, 3433-3439

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

H. Zhang, K. Ye, X. Huang, X. Lin, L. Ma and T. Chen, Inorg. Chem. Front., 2021, 8, 3433 DOI: 10.1039/D1QI00442E

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