Issue 7, 2017

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

Abstract

Covering: up to 2017

The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have become increasingly recognised as a rich yet underexplored source of novel antimicrobials, with the potential to combat the looming health threat posed by antibiotic resistance. In this article, we have compiled a comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known. We also provide a detailed discussion of several unusual pathways for antibiotic biosynthesis in Gram-negative bacteria, serving to highlight the exceptional biocatalytic repertoire of this group of microorganisms.

Graphical abstract: Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

Article information

Article type
Review Article
Submitted
31 Jän 2017
First published
26 Jun 2017

Nat. Prod. Rep., 2017,34, 712-783

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

J. Masschelein, M. Jenner and G. L. Challis, Nat. Prod. Rep., 2017, 34, 712 DOI: 10.1039/C7NP00010C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements