Issue 2, 2014
From the journal:

Organic Chemistry Frontiers

Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles†‡

Jinqiang Kuang,a   Bo Chena  and  Shengming Ma*ab  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China
E-mail: masm@sioc.ac.cn
Fax: (+86)-21-6260-9305

b Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry East, China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China

Abstract

An efficient copper-mediated three-component reaction of one molecule of amine and two molecules of nitriles affording fully substituted 1,2,4-triazoles has been developed. A tandem double addition–oxidative cyclization mechanism has been proposed for the synthesis of 1,2,4-triazoles.

Graphical abstract: Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

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Article information

DOI
https://doi.org/10.1039/C4QO00007B
Article type
Research Article
Submitted
08 Jän 2014
Accepted
15 Jän 2014
First published
30 Jän 2014

Org. Chem. Front., 2014,1, 186-189

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Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

J. Kuang, B. Chen and S. Ma, Org. Chem. Front., 2014, 1, 186 DOI: 10.1039/C4QO00007B

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