Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(i) complexes†
Yiming
Zhao, 
a
Fernanda
Meloni,
a
Louise
Male,
a
William D. G.
Brittain,
*b
Benjamin R.
Buckley
*c
and
John S.
Fossey
‡*a
a
Fernanda
Meloni,
a
Louise
Male,
a
William D. G.
Brittain,
*b
Benjamin R.
Buckley
*c
and
John S.
Fossey
‡*a
Abstract
The synthesis of atropisomeric phoshino-triazoles is disclosed. It was found that the introduction of a phosphine functionality onto the 5-position of a 1,2,3-triazole ring could be highly restrictive towards the rotation around a triazole-aryl bond. VT NMR and chiral HPLC studies demonstrated that rotation was restricted even at high temperatures. Gold(I) chloride complexes of single-enantiomer phosphines were prepared and again demonstrated to be conformationally stable.
- This article is part of the themed collection: In memory of John S. Fossey – CAtalysis and SEnsing (CASE)
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