Issue 24, 2021

Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

Abstract

Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects. In vivo fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without in vivo toxicity, which was consistent with the findings of ex vivo imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.

Graphical abstract: Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

Supplementary files

Article information

Article type
Paper
Submitted
16 Mär 2021
Accepted
11 Mai 2021
First published
12 Mai 2021

J. Mater. Chem. B, 2021,9, 4857-4862

Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

A. A. Elbatrawy, D. S. Lee, S. B. Lee, H. Jeon, S. Lee, K. Kang, S. Sung, Y. R. Han, S. J. Cho, D. Kim, K. S. Kim, G. Nam and Y. H. Jeon, J. Mater. Chem. B, 2021, 9, 4857 DOI: 10.1039/D1TB00568E

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