Issue 7, 2021

Rhodium-catalyzed enone carbonyl directed C–H activation for the synthesis of indanones containing all-carbon quaternary centers

Abstract

Rh(III)-Catalyzed enone carbonyl directed annulative coupling of α-aroyl ketene dithioacetals and diazo compounds has been realized via aryl and olefinic C–H bond activation. This transformation offers highly functionalized indanone derivatives bearing a quaternary carbon stereocenter at the β-position. The protocol exhibits high efficiency, broad substrate scope, and high compatibility with functional groups.

Graphical abstract: Rhodium-catalyzed enone carbonyl directed C–H activation for the synthesis of indanones containing all-carbon quaternary centers

Supplementary files

Article information

Article type
Research Article
Submitted
12 Jän 2021
Accepted
03 Feb 2021
First published
05 Feb 2021

Org. Chem. Front., 2021,8, 1447-1453

Rhodium-catalyzed enone carbonyl directed C–H activation for the synthesis of indanones containing all-carbon quaternary centers

J. Lou, W. Han, Z. Liu and J. Xiao, Org. Chem. Front., 2021, 8, 1447 DOI: 10.1039/D1QO00056J

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