Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence†
Madushani
Dharmarwardana, 
a
Janel M.
Dempsey,
a
Sasha
Padilla-Coley,
a
Tia S.
Jarvis,
a
Kejia
Shi,
a
Kirk M.
Atkinson
a
and
Bradley D.
Smith
*a
a
Janel M.
Dempsey,
a
Sasha
Padilla-Coley,
a
Tia S.
Jarvis,
a
Kejia
Shi,
a
Kirk M.
Atkinson
a
and
Bradley D.
Smith
*a
Abstract
A supramolecular dye-capture system comprising anionic amidosquaraine guest and macrocyclic tetralactam host exhibits nanomolar affinity and “turn on” visible fluorescence. Utility is demonstrated with a new fluorescent assay for liposome leakage induced by the biomedically important enzyme phospholipase A2.
- This article is part of the themed collection: Host-Guest Chemistry
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