Issue 62, 2021
From the journal:

Chemical Communications

Micelle enabled C(sp2)–C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis†

Ning Ye, ORCID logo *a   Bin Wu, ORCID logo *a   Kangming Zhao,‡a   Xiaobin Ge,‡a   Yu Zheng,a   Xiaodong Shen,a   Lei Shi,a   Margery Cortes-Clerget,b   Morgan Louis Regnier,b   Michael Parmentier ORCID logo b  and  Fabrice Gallou ORCID logo *b  

* Corresponding authors

a Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, Jiangsu 215537, China
E-mail: ning.ye@novartis.com, bin-3.wu@novartis.com

b Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland
E-mail: fabrice.gallou@novartis.com

Abstract

A robust and sustainable C(sp2)–C(sp3) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large scale.

Graphical abstract: Micelle enabled C(sp2)–C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis

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Article information

DOI
https://doi.org/10.1039/D1CC02885E
Article type
Communication
Submitted
01 Jun 2021
Accepted
30 Jun 2021
First published
30 Jun 2021

Chem. Commun., 2021,57, 7629-7632

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Micelle enabled C(sp2)–C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis

N. Ye, B. Wu, K. Zhao, X. Ge, Y. Zheng, X. Shen, L. Shi, M. Cortes-Clerget, M. L. Regnier, M. Parmentier and F. Gallou, Chem. Commun., 2021, 57, 7629 DOI: 10.1039/D1CC02885E

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